Product Name
Substance-K receptor (Tacr2), Recombinant Protein
Full Product Name
Recombinant Mouse Substance-K receptor (Tacr2)
Product Synonym Names
Recombinant Substance-K receptor (Tacr2); Substance-K receptor; SKR; NK-2 receptor; NK-2R Neurokinin A receptor Tachykinin receptor 2
Product Gene Name
Tacr2 recombinant protein
[Similar Products]
Product Synonym Gene Name
Tacr2; Tac2r[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
MGAHASVTDT NILSGLESNA TGVTAFSMPG WQLALWATAY LALVLVAVTG NATVIWIILA HERMRTVTNY FIINLALADL CMAAFNATFN FIYASHNIWY FGSTFCYFQN LFPVTAMFVS IYSMTAIAAD RYMAIVHPFQ PRLSAPSTKA VIAVIWLVAL ALASPQCFYS TITVDQGATK CVVAWPNDNG GKMLLLYHLV VFVLIYFLPL VVMFAAYSVI GLTLWKRAVP RHQAHGANLR HLQAKKKFVK AMVLVVVTFA ICWLPYHLYF ILGTFQEDIY YRKFIQQVYL ALFWLAMSST MYNPIIYCCL NHRFRSGFRL AFRCCPWGTP TEEDRLELTH TPSISRRVNR CHTKETLFMT GDMTHSEATN GQVGGPQDGE PAGP
Chromosome Location
Chromosome: 10; NC_000076.6 (62252438..62265990). Location: 10 B4; 10
3D Structure
ModBase 3D Structure for P30549
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>=90% (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Mus musculus (Mouse)
Preparation and Storage
Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Tacr2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for Tacr2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_033340.3
[Other Products]
NCBI GenBank Nucleotide #
NM_009314.4
[Other Products]
UniProt Primary Accession #
P30549
[Other Products]
UniProt Related Accession #
P30549[Other Products]
Molecular Weight
43,114 Da[Similar Products]
NCBI Official Full Name
substance-K receptor
NCBI Official Synonym Full Names
tachykinin receptor 2
NCBI Official Symbol
Tacr2??[Similar Products]
NCBI Official Synonym Symbols
Skr; Nk2r; Tac2r
??[Similar Products]
NCBI Protein Information
substance-K receptor; NK-2R; NK-2 receptor; substance K receptor; neurokinin A receptor; 7 transmembrane receptor; tachykinin NK-2 receptor
UniProt Protein Name
Substance-K receptor
UniProt Synonym Protein Names
NK-2 receptor; NK-2R; Neurokinin A receptor; Tachykinin receptor 2
Protein Family
Substance-K receptor
UniProt Gene Name
Tacr2??[Similar Products]
UniProt Synonym Gene Names
Tac2r; SKR; NK-2R??[Similar Products]
UniProt Entry Name
NK2R_MOUSE
UniProt Comments for Tacr2
TACR2: This is a receptor for the tachykinin neuropeptide substance K (neurokinin A). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance K > neuromedin-K > substance P. Belongs to the G-protein coupled receptor 1 family.
Protein type: Receptor, GPCR; GPCR, family 1; Motility/polarity/chemotaxis; Membrane protein, multi-pass; Membrane protein, integral
Cellular Component: membrane; cell; plasma membrane; integral to membrane
Molecular Function: G-protein coupled receptor activity; substance K receptor activity; signal transducer activity; tachykinin receptor activity
Biological Process: synaptic transmission; G-protein coupled receptor protein signaling pathway; negative regulation of luteinizing hormone secretion; tachykinin signaling pathway; intestine smooth muscle contraction; neuropeptide signaling pathway; operant conditioning; positive regulation of ion transport; signal transduction; positive regulation of vascular permeability; positive regulation of acetylcholine secretion
Research Articles on Tacr2
1. NK2R-dependent neuropeptide signaling regulates Ag-specific T cell responses via activation of DC function
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
