Product Name
Chloride channel protein 2 (CLCN2), Recombinant Protein
Full Product Name
Recombinant Human Chloride channel protein 2 (CLCN2) , partial
Product Gene Name
CLCN2 recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
549-898. Partial, provide one of the cytoplasmic domains at the C-terminal.
Sequence
QPSLYDSIIR IKKLPYLPEL GWGRHQQYRV RVEDIMVRDV PHVALSCTFR DLRLALHRTK GRMLALVESP ESMILLGSIE RSQVVALLGA QLSPARRRQH MQERRATQTS PLSDQEGPPT PEASVCFQVN TEDSAFPAAR GETHKPLKPA LKRGPSVTRN LGESPTGSAE SAGIALRSLF CGSPPPEAAS EKLESCEKRK LKRVRISLAS DADLEGEMSP EEILEWEEQQ LDEPVNFSDC KIDPAPFQLV ERTSLHKTHT IFSLLGVDHA YVTSIGRLIG IVTLKELRKA IEGSVTAQGV KVRPPLASFR DSATSSSDTE TTEVHALWGP HSRHGLPREG SPSDSDDKCQ
3D Structure
ModBase 3D Structure for P51788
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Homo sapiens (Human)
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of CLCN2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for CLCN2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001164558.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001171087.2
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UniProt Primary Accession #
P51788
[Other Products]
UniProt Secondary Accession #
O14864; Q6IPA9; Q8WU13; B4DQT9; B4DZ58; E9PBD9; E9PCD2[Other Products]
UniProt Related Accession #
P51788[Other Products]
Molecular Weight
95,399 Da
NCBI Official Full Name
chloride channel protein 2 isoform 2
NCBI Official Synonym Full Names
chloride voltage-gated channel 2
NCBI Official Symbol
CLCN2??[Similar Products]
NCBI Official Synonym Symbols
CLC2; ECA2; ECA3; EGI3; EGMA; EJM6; EJM8; CIC-2; EGI11; LKPAT; clC-2
??[Similar Products]
NCBI Protein Information
chloride channel protein 2
UniProt Protein Name
Chloride channel protein 2
Protein Family
Chloride channel protein
UniProt Gene Name
CLCN2??[Similar Products]
UniProt Synonym Gene Names
ClC-2??[Similar Products]
NCBI Summary for CLCN2
This gene encodes a voltage-gated chloride channel. The encoded protein is a transmembrane protein that maintains chloride ion homeostasis in various cells. Defects in this gene may be a cause of certain epilepsies. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]
UniProt Comments for CLCN2
Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport.
Research Articles on CLCN2
1. The findings show that RGET691 of human ClC-2 (possible ) plays an important functional role in fatty acid activation of human ClC-2.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
