Product Name
Barttin (BSND), Polyclonal Antibody
Full Product Name
Rabbit anti-human Barttin polyclonal Antibody(BSND)
Product Synonym Names
BSND; BART
Product Gene Name
anti-BSND antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q8WZ55
Purity/Purification
Antigen Affinity Purified
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Immunogen
Recombinant human Barttin protein (54-320aa)
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-49609 / sc-49607 / sc-49611
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-BSND antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-BSND antibody
Functions as a beta-subunit for CLCNKA and CLCNKB chloride channels. In the kidney CLCNK/BSND heteromers mediate chloride reabsorption by facilitating its basolateral efflux. In the stria, CLCNK/BSND channels drive potassium secretion by recycling chloride for the basolateral SLC12A2 cotransporter.
Applications Tested/Suitable for anti-BSND antibody
ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-BSND antibody
Recommended dilution: IHC:1:20-1:200
Immunohistochemistry (IHC) of anti-BSND antibody
Immunohistochemistry of paraffin-embedded human breast cancer using MBS1496401 at dilution 1:100
Immunohistochemistry (IHC) of anti-BSND antibody
Immunohistochemistry of paraffin-embedded human kidney using MBS1496401 at dilution 1:100
NCBI/Uniprot data below describe general gene information for BSND. It may not necessarily be applicable to this product.
NCBI Accession #
NP_476517.1
[Other Products]
NCBI GenBank Nucleotide #
NM_057176.2
[Other Products]
UniProt Primary Accession #
Q8WZ55
[Other Products]
UniProt Secondary Accession #
Q6NT28[Other Products]
UniProt Related Accession #
Q8WZ55[Other Products]
Molecular Weight
35,197 Da
NCBI Official Full Name
barttin
NCBI Official Synonym Full Names
barttin CLCNK type accessory beta subunit
NCBI Official Symbol
BSND??[Similar Products]
NCBI Official Synonym Symbols
BART; DFNB73
??[Similar Products]
NCBI Protein Information
barttin
UniProt Protein Name
Barttin
UniProt Gene Name
BSND??[Similar Products]
UniProt Synonym Gene Names
BART??[Similar Products]
UniProt Entry Name
BSND_HUMAN
NCBI Summary for BSND
This gene encodes an essential beta subunit for CLC chloride channels. These heteromeric channels localize to basolateral membranes of renal tubules and of potassium-secreting epithelia of the inner ear. Mutations in this gene have been associated with Bartter syndrome with sensorineural deafness. [provided by RefSeq, Jul 2008]
UniProt Comments for BSND
BSND: Functions as a beta-subunit for CLCNKA and CLCNKB chloride channels. In the kidney CLCNK/BSND heteromers mediate chloride reabsorption by facilitating its basolateral efflux. In the stria, CLCNK/BSND channels drive potassium secretion by recycling chloride for the basolateral SLC12A2 cotransporter. Defects in BSND are the cause of Bartter syndrome type 4A (BS4A); also known as infantile Bartter syndrome with sensorineural deafness. BS refers to a group of autosomal recessive disorders characterized by impaired salt reabsorption in the thick ascending loop of Henle with pronounced salt wasting, hypokalemic metabolic alkalosis, and varying degrees of hypercalciuria. BS4A is associated with sensorineural deafness.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Transporter, ion channel; Transporter
Chromosomal Location of Human Ortholog: 1p32.1
Cellular Component: basolateral plasma membrane; cytoplasm; integral to plasma membrane; plasma membrane; protein complex
Molecular Function: chloride channel activity; chloride channel regulator activity
Biological Process: transmembrane transport
Disease: Bartter Syndrome, Type 4a
Research Articles on BSND
1. These results demonstrate that mutations in a cluster of hydrophobic residues within transmembrane domain 1 affect barttin-CLC-K interaction and impair gating modification by the accessory subunit
Precautions
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Disclaimer
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