Product Name
CLCN2, cDNA Clone
Full Product Name
CLCN2 cDNA Clone
Product Gene Name
CLCN2 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atggctgcct ggttcccaga tggaattcat acggacagca gcacctaccg gattgtgcct gggggctacg ctgtggtcgg ggcagctgcg ctggcaggag cggtgacaca cacagtgtcc acggctgtga tcgtgttcga gctcacaggc cagattgccc acatcctgcc tgtcatgatc gtcgtcatcc tggccaacgc tgtcgcccag agtctgcagc cctccctcta tgacagcatc atccgaatca agaaactgcc ctacctgcct gagctcggct ggggccgcca ccagcagtac cgggtgcgtg tggaggacat catggtgcgg gatgttcccc atgtggccct cagctgcacc ttccgggacc tgcgtttggc actgcacagg accaagggcc gaatgctggc cctagtggag tcccctgagt ccatgattct gctgggctcc atcgagcgtt cacaggtggt ggcattgttg ggggcccagc tgagcccagc ccgccggcgg cagcacatgc aggagcgcag agccacccag acctctccac tatctgatca ggagggtccc cctacccctg aggcttctgt ctgcttccag gtgaacacag aagactcagc cttcccagca gcccgggggg agacccacaa gcccctaaag cctgcactca agagggggcc cagtgtcacc aggaacctcg gagagagtcc cacagggagc gcagagtcgg caggcatcgc cctccggagc ctcttctgtg gcagtccacc ccctgaggct gcttcggaga agttggaatc ctgtgagaag cgcaagctga agcgtgtccg aatctccctg gcaagtgacg cggacctgga aggcgagatg agccctgaag agactcacac tatcttctca ctgctgggag tggaccatgc ttatgtcacc agtattggca gactcattgg aatcgttact ctaaaggagc tccggaaggc catcgagggc tctgtcacag cacagggtgt gaaagtccgg ccgcccctcg ccagcttccg agacagtgcc accagcagca gtgacacgga gaccactgag gtgcatgcac tctgggggcc ccactcccgt catggcctcc cccgggaggg cagcccttcc gacagcgacg acaaatgcca atga
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of CLCN2 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for CLCN2. It may not necessarily be applicable to this product.
NCBI Accession #
BC021578
[Other Products]
UniProt Secondary Accession #
O14864; Q6IPA9; Q8WU13; B4DQT9; B4DZ58; E9PBD9; E9PCD2[Other Products]
UniProt Related Accession #
P51788[Other Products]
Molecular Weight
95,399 Da
NCBI Official Full Name
Homo sapiens chloride channel 2, mRNA
NCBI Official Synonym Full Names
chloride voltage-gated channel 2
NCBI Official Symbol
CLCN2??[Similar Products]
NCBI Official Synonym Symbols
CLC2; ECA2; ECA3; EGI3; EGMA; EJM6; EJM8; CIC-2; EGI11; LKPAT; clC-2
??[Similar Products]
NCBI Protein Information
chloride channel protein 2
UniProt Protein Name
Chloride channel protein 2
Protein Family
Chloride channel protein
UniProt Gene Name
CLCN2??[Similar Products]
UniProt Synonym Gene Names
ClC-2??[Similar Products]
UniProt Entry Name
CLCN2_HUMAN
NCBI Summary for CLCN2
This gene encodes a voltage-gated chloride channel. The encoded protein is a transmembrane protein that maintains chloride ion homeostasis in various cells. Defects in this gene may be a cause of certain epilepsies. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]
UniProt Comments for CLCN2
CLCN2: Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. Defects in CLCN2 are associated with susceptibility to epilepsy, idiopathic generalized type 11 (EIG11). A disorder characterized by recurring generalized seizures in the absence of detectable brain lesions and/or metabolic abnormalities. Generalized seizures arise diffusely and simultaneously from both hemispheres of the brain. Defects in CLCN2 are associated with juvenile absence epilepsy type 2 (JAE2). JAE is a subtype of idiopathic generalized epilepsy (IGE) characterized by onset occurring around puberty, absence seizures, generalized tonic- clonic seizures (GTCS), GTCS on awakening and myoclonic seizures. Defects in CLCN2 are associated with juvenile myoclonic epilepsy type 8 (EJM8). A subtype of idiopathic generalized epilepsy. Patients have afebrile seizures only, with onset in adolescence (rather than in childhood) and myoclonic jerks which usually occur after awakening and are triggered by sleep deprivation and fatigue. Belongs to the chloride channel (TC 2.A.49) family. ClC-2/CLCN2 subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Transporter; Channel, chloride; Transporter, ion channel
Chromosomal Location of Human Ortholog: 3q27.1
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: chloride ion binding; voltage-gated chloride channel activity
Biological Process: transport
Disease: Epilepsy, Idiopathic Generalized, Susceptibility To, 11; Leukoencephalopathy With Ataxia
Research Articles on CLCN2
1. The extracellular domain of GlialCAM is necessary for cell junction targeting and for mediating interactions with itself or with MLC1 and ClC-2.
Precautions
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Disclaimer
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