Product Name
CYBB, cDNA Clone
Full Product Name
CYBB cDNA Clone
Product Gene Name
CYBB cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atggggaact gggctgtgaa tgaggggctc tccatttttg tcattctggt ttggctgggg ttgaacgtct tcctctttgt ctggtattac cgggtttatg atattccacc taagttcttt tacacaagaa aacttcttgg gtcagcactg gcactggcca gggcccctgc agcctgcctg aatttcaact gcatgctgat tctcttgcca gtctgtcgaa atctgctgtc cttcctcagg ggttccagtg cgtgctgctc aacaagagtt cgaagacaac tggacaggaa tctcaccttt cataaaatgg tggcatggat gattgcactt cactctgcga ttcacaccat tgcacatcta tttaatgtgg aatggtgtgt gaatgcccga gtcaataatt ctgatcctta ttcagtagca ctctctgaac ttggagacag gcaaaatgaa agttatctca attttgctcg aaagagaata aagaaccctg aaggaggcct gtacctggct gtgaccctgt tggcaggcat cactggagtt gtcatcacgc tgtgcctcat attaattatc acttcctcca ccaaaaccat ccggaggtct tactttgaag tcttttggta cacacatcat ctctttgtga tcttcttcat tggccttgcc atccatggag ctgaacgaat tgtacgtggg cagaccgcag agagtttggc tgtgcataat ataacagttt gtgaacaaaa aatctcagaa tggggaaaaa taaaggaatg cccaatccct cagtttgctg gaaaccctcc tatgacttgg aaatggatag tgggtcccat gtttctgtat ctctgtgaga ggttggtgcg gttttggcga tctcaacaga aggtggtcat caccaaggtg gtcactcacc ctttcaaaac catcgagcta cagatgaaga agaaggggtt caaaatggaa gtgggacaat acatttttgt caagtgccca aaggtgtcca agctggagtg gcaccctttt acactgacat ccgcccctga ggaagacttc tttagtatcc atatccgcat cgttggggac tggacagagg ggctgttcaa tgcttgtggc tgtgataagc aggagtttca agatgcgtgg aaactaccta agatagcggt tgatgggccc tttggcactg ccagtgaaga tgtgttcagc tatgaggtgg tgatgttagt gggagcaggg attggggtca cacccttcgc atccattctc aagtcagtct ggtacaaata ttgcaataac gccaccaatc tgaagctcaa aaagatctac ttctactggc tgtgccggga cacacatgcc tttgagtggt ttgcagatct gctgcaactg ctggagagcc agatgcagga aaggaacaat gccggcttcc tcagctacaa catctacctc actggctggg atgagtctca ggccaatcac tttgctgtgc accatgatga ggagaaagat gtgatcacag gcctgaaaca aaagactttg tatggacggc ccaactggga taatgaattc aagacaattg caagtcaaca ccctaatacc agaataggag ttttcctctg tggacctgaa gccttggctg aaaccctgag taaacaaagc atctccaact ctgagtctgg ccctcgggga gtgcatttca ttttcaacaa ggaaaacttc taa
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of CYBB cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for CYBB. It may not necessarily be applicable to this product.
NCBI Accession #
BC032720
[Other Products]
UniProt Secondary Accession #
Q2PP16; A8K138[Other Products]
UniProt Related Accession #
P04839[Other Products]
Molecular Weight
65,336 Da
NCBI Official Full Name
Homo sapiens cytochrome b-245, beta polypeptide, mRNA
NCBI Official Synonym Full Names
cytochrome b-245 beta chain
NCBI Official Symbol
CYBB??[Similar Products]
NCBI Official Synonym Symbols
CGD; NOX2; IMD34; AMCBX2; GP91-1; GP91PHOX; p91-PHOX; GP91-PHOX
??[Similar Products]
NCBI Protein Information
cytochrome b-245 heavy chain
UniProt Protein Name
Cytochrome b-245 heavy chain
UniProt Synonym Protein Names
CGD91-phox; Cytochrome b(558) subunit beta; Cytochrome b558 subunit beta; Heme-binding membrane glycoprotein gp91phox; NADPH oxidase 2; Neutrophil cytochrome b 91 kDa polypeptide; Superoxide-generating NADPH oxidase heavy chain subunit; gp91-1; gp91-phox; p22 phagocyte B-cytochrome
Protein Family
Cytochrome
UniProt Gene Name
CYBB??[Similar Products]
UniProt Synonym Gene Names
NOX2; Cytochrome b558 subunit beta??[Similar Products]
UniProt Entry Name
CY24B_HUMAN
NCBI Summary for CYBB
Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell's respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole. [provided by RefSeq, Jul 2008]
UniProt Comments for CYBB
CYBB: Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc. Defects in CYBB are a cause of granulomatous disease,chronic, X-linked (CGD). A disorder characterized by the inability of neutrophils and phagocytes to kill microbes that they have ingested. Patients suffer from life- threatening bacterial/fungal infections. Defects in CYBB are a cause of mycobacteriosis atypical X-linked type 2 (AMCBX2). A rare condition characterized by predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine and environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections.
Protein type: Membrane protein, multi-pass; Oxidoreductase; Mitochondrial; Membrane protein, integral; EC 1.-.-.-
Chromosomal Location of Human Ortholog: Xp21.1
Cellular Component: endoplasmic reticulum membrane; integral to plasma membrane; NADPH oxidase complex; phagocytic vesicle membrane; plasma membrane
Molecular Function: electron carrier activity; FAD binding; heme binding; protein binding; protein heterodimerization activity; superoxide-generating NADPH oxidase activity
Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; cell redox homeostasis; inflammatory response; innate immune response; respiratory burst; response to reactive oxygen species; superoxide metabolic process; superoxide release; vascular endothelial growth factor receptor signaling pathway
Disease: Granulomatous Disease, Chronic, X-linked; Immunodeficiency 34
Research Articles on CYBB
1. Furthermore, a direct interaction between AnkA and HDAC1 was detected at the CYBB promoter, and was critical for AnkA-mediated CYBB repression.
Precautions
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Disclaimer
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