Full Product Name
CYBB Polyclonal Antibody
Product Synonym Names
AMCBX2; CGD; CGD91-phox; CY24B; CYBB; Cytochrome b 245; beta polypeptide; Cytochrome b(558) beta chain; Cytochrome b(558) subunit beta; Cytochrome b-245 heavy chain; Cytochrome b558 subunit beta; GP91 PHOX; gp91-1; gp91-phox; GP91PHOX; Heme-binding membrane glycoprotein gp91phox; NADPH oxidase 2; Neutrophil cytochrome b 91 kDa polypeptide; NOX2; p22 phagocyte B-cytochrome; P91 PHOX; p91-PHOX; Superoxide-generating NADPH oxidase heavy chain subunit
Product Gene Name
anti-CYBB antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q61093
Species Reactivity
Mouse, Rat
Purity/Purification
Affinity Purification
Form/Format
PBS with 0.02% sodium azide, 100 mug/ml BSA and 50% glycerol.
Concentration
270 mug/mL (lot specific)
Immunogen
Recombinant protein corresponding to Mouse NOX2
Preparation and Storage
Store at -20 degree C. Avoid freeze/thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-CYBB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CYBB antibody
Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles.
Product Categories/Family for anti-CYBB antibody
Cancer; Metabolism; Immunology
Applications Tested/Suitable for anti-CYBB antibody
Immunohistochemistry (IHC)
Application Notes for anti-CYBB antibody
IHC: 1:400-1:1200
Immunohistochemistry (IHC) of anti-CYBB antibody
Immunohistochemistry analysis of paraffin-embedded mouse spleen using CYBB Polyclonal Antibody at dilution of 1:400.
Immunohistochemistry (IHC) of anti-CYBB antibody
Immunohistochemistry analysis of paraffin-embedded rat spleen using CYBB Polyclonal Antibody at dilution of 1:400.
NCBI/Uniprot data below describe general gene information for CYBB. It may not necessarily be applicable to this product.
NCBI Accession #
NP_031833.3
[Other Products]
NCBI GenBank Nucleotide #
NM_007807.5
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UniProt Primary Accession #
Q61093
[Other Products]
UniProt Related Accession #
Q61093[Other Products]
Molecular Weight
65,305 Da
NCBI Official Full Name
cytochrome b-245 heavy chain
NCBI Official Synonym Full Names
cytochrome b-245, beta polypeptide
NCBI Official Symbol
Cybb??[Similar Products]
NCBI Official Synonym Symbols
Cgd; Cyd; Nox2; C88302; gp91-1; gp91phox; CGD91-phox
??[Similar Products]
NCBI Protein Information
cytochrome b-245 heavy chain
UniProt Protein Name
Cytochrome b-245 heavy chain
UniProt Synonym Protein Names
CGD91-phox; Cytochrome b(558) subunit beta; Cytochrome b558 subunit beta; Heme-binding membrane glycoprotein gp91phox; Neutrophil cytochrome b 91 kDa polypeptide; gp91-1; gp91-phox; p22 phagocyte B-cytochrome
Protein Family
Cytochrome
UniProt Gene Name
Cybb??[Similar Products]
UniProt Synonym Gene Names
Cytochrome b558 subunit beta??[Similar Products]
NCBI Summary for CYBB
This gene encodes the heavy chain component of a heterodimeric transmembrane ion transporter composed of both a heavy and a light chain. This transporter mediates the transfer of electrons from nicotinamide adenine dinucleotide phosphate (NADPH) to oxygen to generate superoxide. This reaction is important in the innate immune response to pathogens. However, increased activity of the encoded protein also leads to the generation of reactive oxygen species that result in oxidative stress and can cause tissue damage. Conversely, loss of function of the related gene in human causes chronic granulomatous disease. Alternative splicing results in multiple transcript variants, although the full-length nature of some of these variants has not been determined. [provided by RefSeq, May 2013]
UniProt Comments for CYBB
Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H+ currents of resting phagocytes.
Research Articles on CYBB
1. Combination of exogenous and endogenous environmental factors with minimally toxic dose synergistically propagates dopaminergic neurodegeneration through activating microglial NOX2.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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