Product Name
CLCN2, Polyclonal Antibody
Popular Item
Full Product Name
CLCN2 Antibody
Product Synonym Names
Chloride Channel 2; Chloride channel protein 2; Chloride channel, voltage sensitive 2; CIC 2; CIC2; ClC-2; CLC2; Clcn2; CLCN2_HUMAN; ECA2; ECA3; EG13; EGI11; EGMA; EJM6; EJM8; PKA-activated chloride channel
Product Gene Name
anti-CLCN2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P51788
Species Reactivity
Human, Mouse, Rat
Specificity
CLCN2 antibody detects endogenous levels of total CLCN2
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
Form/Format
Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (lot specific)
Immunogen
A synthesized peptide derived from human CLCN2
Subcellular Location
Membrane.
Tissue Specificity
Ubiquitously expressed. Moderately expressed in aortic and coronary vascular smooth muscle cells and expressed at a low level in aortic endothelial cells.
Predicted Cross Reactivity
Pig, Bovine, Horse, Rabbit, Dog, Xenopus
Similarity
Pig (100%), Bovine (100%), Horse (100%), Rabbit (100%), Dog (100%), Xenopus (83%)
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available, please inquire.
Other Notes
Small volumes of anti-CLCN2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CLCN2 antibody
Function: Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport.
Post-translational Modifications: Phosphorylated. Activated by dephosphorylation.
Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClC-2/CLCN2 subfamily.
Applications Tested/Suitable for anti-CLCN2 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-CLCN2 antibody
WB: 1:1000-3000
Western Blot (WB) of anti-CLCN2 antibody
Western blot analysis of CLCN2 using K562 whole cell lysates
NCBI/Uniprot data below describe general gene information for CLCN2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001164558.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001171087.2
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UniProt Primary Accession #
P51788
[Other Products]
UniProt Secondary Accession #
O14864; Q6IPA9; Q8WU13; B4DQT9; B4DZ58; E9PBD9; E9PCD2[Other Products]
UniProt Related Accession #
P51788[Other Products]
Molecular Weight
Observed: 98 kDa
Predicted: 99 kDa
NCBI Official Full Name
chloride channel protein 2 isoform 2
NCBI Official Synonym Full Names
chloride voltage-gated channel 2
NCBI Official Symbol
CLCN2??[Similar Products]
NCBI Official Synonym Symbols
CLC2; ECA2; ECA3; EGI3; EGMA; EJM6; EJM8; CIC-2; EGI11; HALD2; LKPAT; clC-2
??[Similar Products]
NCBI Protein Information
chloride channel protein 2
UniProt Protein Name
Chloride channel protein 2
Protein Family
Chloride channel protein
UniProt Gene Name
CLCN2??[Similar Products]
UniProt Synonym Gene Names
ClC-2??[Similar Products]
NCBI Summary for CLCN2
This gene encodes a voltage-gated chloride channel. The encoded protein is a transmembrane protein that maintains chloride ion homeostasis in various cells. Defects in this gene may be a cause of certain epilepsies. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]
UniProt Comments for CLCN2
Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport.
Research Articles on CLCN2
1. The inhibitory effects of ClC-2 knockout on HBVSMC proliferation and motility were associated with inactivation of the Wnt/beta-catenin signaling pathway, as evidenced by inhibition of beta-catenin phosphorylation and nuclear translocation, and decrease of GSK-3beta phosphorylation and survivin and cyclin D1 expression.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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