Excitatory amino-acid carrier 1; excitatory amino acid transporter 3; EAAT3; Neuronal and epithelial glutamate transporter; sodium dependent glutamate/aspartate transporter 3; solute carrier family 1 member 1; and Slc1a1

For Research Use Only. Not for use in diagnostic procedures.

Monoclonal

IgG1

S180-41

Mouse

Protein G Purified

1mg/mL (lot specific)

-20 degree C

Small volumes of anti-SLC1A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Background Info: Detects ~60kDa

Scientific Background: SLC1A1/EAAT3/EAAC1, a member of this transporter family, is expressed throughout the body, particularly in brain, intestine, liver, heart and kidney. Functional defects of the SLC1A1 gene are found in patients of dicarboxylicamino aciduria.

Transporters

Immunoprecipitation (IP)

1:1000 (WB)

Western Blot analysis of Rat brain membrane lysate showing detection of EAAT3 protein using Mouse Anti-EAAT3 Monoclonal Antibody, Clone S180-41. Primary Antibody: Mouse Anti-EAAT3 Monoclonal Antibody at 1:1000.

57,100 Da[Similar Products]

solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1

excitatory amino acid transporter 3; excitatory amino acid carrier 1; solute carrier family 1 member 1; neuronal and epithelial glutamate transporter; sodium-dependent glutamate/aspartate transporter 3

Excitatory amino acid transporter 3

EAAC1; EAAT3??[Similar Products]

EAA3_HUMAN

This gene encodes a member of the high-affinity glutamate transporters that play an essential role in transporting glutamate across plasma membranes. In brain, these transporters are crucial in terminating the postsynaptic action of the neurotransmitter glutamate, and in maintaining extracellular glutamate concentrations below neurotoxic levels. This transporter also transports aspartate, and mutations in this gene are thought to cause dicarboxylicamino aciduria, also known as glutamate-aspartate transport defect. [provided by RefSeq, Mar 2010]

SLC1A1: Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Negatively regulated by ARL6IP5. Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. SLC1A1 subfamily.

Protein type: Transporter, SLC family; Membrane protein, multi-pass; Membrane protein, integral; Transporter

Chromosomal Location of Human Ortholog: 9p24

Cellular Component: membrane; integral to plasma membrane; apical plasma membrane; plasma membrane

Molecular Function: glutamate binding; cysteine transmembrane transporter activity; sodium:dicarboxylate symporter activity; glutamate:sodium symporter activity; L-glutamate transmembrane transporter activity

Biological Process: L-glutamate import; synaptic transmission; cysteine transport; ion transport; transmembrane transport; protein homooligomerization

Disease: Schizophrenia 18

1. Smith C. P., et al., (1994) Genomics 20:335-336. 2.?? Kanai Y., and Hediger M. A. (1992) Nature 360:467-471.

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