Full Product Name
AICDA Antibody
Product Gene Name
anti-AICDA antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9GZX7
Species Reactivity
Human, Mouse
Form/Format
Purified by peptide affinity column containing 1% BSA and 0.02% NaN3
Preparation and Storage
Already reconstituted in 200ul sterile H2O. The antibody is stable for at least one year when stored at-20 degree C after reconstitution. Avoid repeated freeze/defrost cycles.
Other Notes
Small volumes of anti-AICDA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-AICDA antibody
Rabbit polyclonal AICDA(1) antibody was raised against a 16 amino acid peptide corresponding to near the N terminal residues of Human AICDA.
Product Categories/Family for anti-AICDA antibody
Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
Applications Tested/Suitable for anti-AICDA antibody
Peptide ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-AICDA antibody
Peptide ELISA: 1:1,000-1:10,000
WB: 1:200-1,000
IHC: 1:100-500
Testing Data of anti-AICDA antibody
Testing Data of anti-AICDA antibody
NCBI/Uniprot data below describe general gene information for AICDA. It may not necessarily be applicable to this product.
NCBI Accession #
NP_065712.1
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NCBI GenBank Nucleotide #
NM_020661.3
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UniProt Primary Accession #
Q9GZX7
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UniProt Secondary Accession #
Q6QJ81; Q8NFC1[Other Products]
UniProt Related Accession #
Q9GZX7[Other Products]
Molecular Weight
22,614 Da
NCBI Official Full Name
single-stranded DNA cytosine deaminase isoform 1
NCBI Official Synonym Full Names
activation induced cytidine deaminase
NCBI Official Symbol
AICDA??[Similar Products]
NCBI Official Synonym Symbols
AID; ARP2; CDA2; HIGM2; HEL-S-284
??[Similar Products]
NCBI Protein Information
single-stranded DNA cytosine deaminase
UniProt Protein Name
Single-stranded DNA cytosine deaminase
UniProt Synonym Protein Names
Activation-induced cytidine deaminase; AID; Cytidine aminohydrolase
Protein Family
Single-stranded DNA cytosine deaminase
UniProt Gene Name
AICDA??[Similar Products]
UniProt Synonym Gene Names
AID; AID??[Similar Products]
NCBI Summary for AICDA
This gene encodes a RNA-editing deaminase that is a member of the cytidine deaminase family. The protein is involved in somatic hypermutation, gene conversion, and class-switch recombination of immunoglobulin genes. Defects in this gene are the cause of autosomal recessive hyper-IgM immunodeficiency syndrome type 2 (HIGM2). [provided by RefSeq, Feb 2009]
UniProt Comments for AICDA
Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses (PubMed:18722174, PubMed:21385873, PubMed:21518874, PubMed:27716525). May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation (PubMed:21496894).
Product References and Citations for anti-AICDA antibody
(1) Muto, T., Muramatsu, M., Taniwaki, M.et, al Isolation, tissue distribution, and chromosomal localization of the human activation-induced cytidine deaminase (AID) gene. Genomics.2000; 68(1):85-88.
Research Articles on AICDA
1. we reported high AID, low miR-181b and high miR-155 expression in de novo ***** B-ALL patients. Univariate high AID or low miR-181b expression was an unfavorable prognostic factor. High AID with low miR-181b or with low miR-155 expression is better in predicting unfavorable OS than univariate factor. High AID with low miR-181b and low miR-155 expression confers worst prognosis.
Precautions
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Disclaimer
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