Product Name
Thyrotropin receptor (Tshr), Recombinant Protein
Full Product Name
Recombinant Mouse Thyrotropin receptor (Tshr), partial
Product Gene Name
Tshr recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
22-413aa, Full Length of Mature Protein
Sequence
KECASPPCEC HQEDDFRVTC KELHRIPSLP PSTQTLKLIE THLKTIPSLA FSSLPNISRI YLSIDATLQR LEPHSFYNLS KMTHIEIRNT RSLTYIDPDA LTELPLLKFL GIFNTGLRIF PDLTKIYSTD IFFILEITDN PYMTSVPENA FQGLCNETLT LKLYNNGFTS VQGHAFNGTK LDAVYLNKNK YLTAIDNDAF GGVYSGPTLL DVSSTSVTAL PSKGLEHLKE LIAKDTWTLK KLPLSLSFLH LTRADLSYPS HCCAFKNQKK IRGILESLMC NESSIRNLRQ RKSVNILRGP IYQEYEEDPG DNSVGYKQNS KFQESPSNSH YYVFFEEQED EVVGFGQELK NPQEETLQAF ESHYDYTVCG DNEDMVCTPK SDEFNPCEDI MG
3D Structure
ModBase 3D Structure for P47750
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Tshr recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
Tshr recombinant protein
This protein is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. Three transcript variants encoding different isoforms have been found for this gene.
NCBI/Uniprot data below describe general gene information for Tshr. It may not necessarily be applicable to this product.
NCBI Accession #
NP_035778.3
[Other Products]
NCBI GenBank Nucleotide #
NM_011648.5
[Other Products]
UniProt Primary Accession #
P47750
[Other Products]
UniProt Secondary Accession #
Q562E4; Q9D697[Other Products]
UniProt Related Accession #
P47750[Other Products]
Molecular Weight
86,583 Da
NCBI Official Full Name
thyrotropin receptor isoform 1
NCBI Official Synonym Full Names
thyroid stimulating hormone receptor
NCBI Official Symbol
Tshr??[Similar Products]
NCBI Official Synonym Symbols
hyt; pet; AI481368; hypothroid
??[Similar Products]
NCBI Protein Information
thyrotropin receptor
UniProt Protein Name
Thyrotropin receptor
UniProt Synonym Protein Names
Thyroid-stimulating hormone receptor; TSH-R
Protein Family
Thyrotropin receptor
UniProt Gene Name
Tshr??[Similar Products]
UniProt Synonym Gene Names
TSH-R??[Similar Products]
UniProt Comments for Tshr
Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism.
Research Articles on Tshr
1. Data indicate that splenic T cells from thyroid stimulating hormone receptor (TSHR) A-subunit primed animals undergoing Graves' orbitopathy (GO) showed proliferative responses to purified TSHR antigen and secreted proinflammatory cytokines.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
