Product Name
Tetraspanin-12 (Tspan12), Recombinant Protein
Full Product Name
Recombinant Mouse Tetraspanin-12 (Tspan12)
Product Gene Name
Tspan12 recombinant protein
[Similar Products]
Product Synonym Gene Name
Tm4sf12[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
1-305aa; full length protein
Sequence
MAREDSVKCL RCLLYALNLL FWLMSISVLA VSAWMRDYLN NVLTLTAETR VEEAVILTYF PVVHPVMIAV CCFLIIVGML GYCGTVKRNL LLLAWYFGTL LVIFCVELAC GVWTYEQEVM VPVQWSDMVT LKARMTNYGL PRYRWLTHAW NYFQREFKCC GVVYFTDWLE MTEMDWPPDS CCVREFPGCS KQAHQEDLSD LYQEGCGKKM YSFLRGTKQL QVLRFLGISI GVTQILAMIL TITLLWALYY DRREPGTDQM LSLKNDTSQH LSCHSVELLK PSLSRIFEHT SMANSFNTHF EMEEL
3D Structure
ModBase 3D Structure for Q8BKT6
Host
Cell Free Expression
Form/Format
Liquid containing glycerol
Storage Buffer
Tris-based buffer, 50% glycerol.
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Tspan12 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for Tspan12 recombinant protein
Transmembrane Protein
Application Notes for Tspan12 recombinant protein
This is a recombinant transmembrane protein expressed in a cell-free expression system.
NCBI/Uniprot data below describe general gene information for Tspan12. It may not necessarily be applicable to this product.
NCBI Accession #
NP_766595.1
[Other Products]
NCBI GenBank Nucleotide #
NM_173007.3
[Other Products]
UniProt Primary Accession #
Q8BKT6
[Other Products]
UniProt Secondary Accession #
Q6P1C3; Q8BZU1[Other Products]
UniProt Related Accession #
Q8BKT6[Other Products]
Molecular Weight
29,757 Da
NCBI Official Full Name
tetraspanin-12
NCBI Official Synonym Full Names
tetraspanin 12
NCBI Official Symbol
Tspan12??[Similar Products]
NCBI Official Synonym Symbols
Tm4sf12; AI426782; AI663988; AW111457; 9030619E17
??[Similar Products]
NCBI Protein Information
tetraspanin-12
UniProt Protein Name
Tetraspanin-12
UniProt Synonym Protein Names
Transmembrane 4 superfamily member 12
UniProt Gene Name
Tspan12??[Similar Products]
UniProt Synonym Gene Names
Tm4sf12; Tspan-12??[Similar Products]
UniProt Entry Name
TSN12_MOUSE
UniProt Comments for Tspan12
TSPAN12: a multi-pass membrane protein. Member of the transmembrane 4 superfamily, also known as the tetraspanin family. Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activate the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). Acts as a regulator of membrane proteinases such as ADAM10 and MMP14/MT1-MMP. Activates ADAM10-dependent cleavage activity of amyloid precursor protein (APP). Activates MMP14/MT1-MMP-dependent cleavage activity. Defects in TSPAN12 are the cause of vitreoretinopathy exudative type 5 (EVR5). It is a disorder of the retinal vasculature characterized by an abrupt cessation of growth of peripheral capillaries, leading to an avascular peripheral retina. Twp isoforms of the human protein are produced by alternative splicing.
Protein type: Receptor, misc.; Membrane protein, integral; Membrane protein, multi-pass
Cellular Component: integral to membrane; integral to plasma membrane; membrane; plasma membrane
Molecular Function: Wnt receptor activity
Biological Process: angiogenesis; cell surface receptor linked signal transduction; regulation of angiogenesis
Research Articles on Tspan12
1. Data indicate that Norrin multimers and TSPAN12 cooperatively promote multimerization of FZD4 and its associated proteins to elicit physiological levels of signaling.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
