Arginine vasopressin Receptor 2 (AVPR2) Stable Cell Line

For Research Use Only. Not for use in diagnostic procedures.

Small volumes of AVPR2 cell line vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

This stable cell line expresses a recombinant human AVPR2. This tetracycline inducible cell line carries a double twin-strep-tag at the N-terminus and a 10-His tag at the C-terminus. There are two TEV cleavage sites inserted between the tags and the receptor for tags' removal.
For all membrane preparations for which radio ligand binding characterization has been conducted, we deliver 1mug/unit, as soon as 1mug is enough to obtain 1000 specific DPM at the Kd concentration of the radio ligand of reference.
For all membrane preparations for which radio ligand binding characterization has not yet been conducted, we deliver 10mug/unit.

Cell Lines For Membrane Receptor Research; GPCR Inducible Stable Cell Lines

33,743 Da

arginine vasopressin receptor 2

vasopressin V2 receptor

Vasopressin V2 receptor

ADHR; DIR; DIR3; V2R; V2R??[Similar Products]

This gene encodes the vasopressin receptor, type 2, also known as the V2 receptor, which belongs to the seven-transmembrane-domain G protein-coupled receptor (GPCR) superfamily, and couples to Gs thus stimulating adenylate cyclase. The subfamily that includes the V2 receptor, the V1a and V1b vasopressin receptors, the oxytocin receptor, and isotocin and mesotocin receptors in non-mammals, is well conserved, though several members signal via other G proteins. All bind similar cyclic nonapeptide hormones. The V2 receptor is expressed in the kidney tubule, predominantly in the distal convoluted tubule and collecting ducts, where its primary property is to respond to the pituitary hormone arginine vasopressin (AVP) by stimulating mechanisms that concentrate the urine and maintain water homeostasis in the organism. When the function of this gene is lost, the disease Nephrogenic Diabetes Insipidus (NDI) results. The V2 receptor is also expressed outside the kidney although its tissue localization is uncertain. When these 'extrarenal receptors' are stimulated by infusion of a V2 selective agonist (dDAVP), a variety of clotting factors are released into the bloodstream. The physiologic importance of this property is not known - its absence does not appear to be detrimental in NDI patients. The gene expression has also been described in fetal lung tissue and lung cancer associated with alternative splicing. [provided by RefSeq, Jul 2008]

Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption.

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