Tumor protein 63; tumor protein p63; AIS antibody; Amplified in squamous cell carcinoma antibody; B(p51A) antibody; B(p51B) antibody; Chronic ulcerative stomatitis protein antibody; CUSP antibody; DN p63 alpha 1 antibody; DNp63 antibody; EEC3 antibody; id:ibd3516 antibody; Keratinocyte transcription factor antibody; Keratinocyte transcription factor KET antibody; KET antibody; LMS antibody; MGC115972 antibody; MGC192897 antibody; NBP antibody; OFC8 antibody; OTTHUMP00000209732 antibody; OTTHUMP00000209733 antibody; OTTHUMP00000209734 antibody; OTTHUMP00000209735 antibody; OTTHUMP00000209737 antibody; OTTHUMP00000209738 antibody; OTTHUMP00000209739 antibody; OTTHUMP00000209740 antibody; OTTHUMP00000209741 antibody; OTTHUMP00000209742 antibody; OTTHUMP00000209743 antibody; OTTHUMP00000209744 antibody; p40 antibody; p51 antibody; P51/P63 antibody; p53 like transcription factor antibody; p53 related protein antibody; p53-related protein p63 antibody; p53CP antibody; p63 antibody; P63_HUMAN antibody; P73 antibody; p73H antibody; p73L antibody; RHS antibody; SHFM4 antibody; TAp63alpha antibody; TP53CP antibody; TP53L antibody; TP63 antibody; TP73 antibody; TP73L antibody; Transformation related protein 63 antibody; Transformation-related protein 63 antibody; Trp53rp1 antibody; Trp63 antibody; Tumor protein 63 antibody; tumor protein 63 kDa with strong homology to p53 antibody; Tumor protein p53-competing protein antibody; Tumor protein p53-like antibody; tumor protein p63 antibody; Tumor protein p63 deltaN isoform delta antibody; Tumor protein p73 antibody; tumor protein p73-like antibody

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

Immunogen affinity purified.

Lyophilized

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Small volumes of anti-TP63 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Description: Rabbit IgG polyclonal antibody for Tumor protein 63(TP63) detection. Tested with WB, IHC-P, ICC in Human, Mouse, Rat.
Background: TP63(Tumor Protein p63), also known as KET, is a protein that in humans is encoded by the TP63 gene. Yang et al.(1998) described the cloning of tumor protein p63, which shows strong homology to the tumor suppressor p53 and the p53-related protein p73. By fluorescence in situ hybridization, Yang et al.(1998) localized the human TP63 gene to chromosome 3q27-q29. Hibi et al.(2000) stated that p53 homologs known variously as p40, p51, p63, and p73L(Trink et al., 1998, Yang et al., 1998, Osada et al., 1998, Senoo et al., 1998) are isoforms of the same gene, which Hibi et al.(2000) referred to as AIS for amplified in squamous cell carcinoma.

Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Immunocytochemistry (ICC)

Anti-p63 antibody, MBS176325, Western blotting
Lane 1: HELA Cell Lysate
Lane 2: SMMC Cell Lysate
Lane 3: COLO320 Cell Lysate
Lane 4: A549 Cell Lysate
Lane 5: SGC Cell Lysate

Anti-p63 antibody, MBS176325, IHC(P)
IHC(P): Human Esophageal Squamous Cell Carcinoma Tissue

Anti-p63 antibody, MBS176325, IHC(P)
IHC(P): Human Esophageal Squamous Cell Carcinoma Tissue

Anti-p63 antibody, MBS176325, IHC(P)
IHC(P): Human Lung Cancer Tissue

Anti-p63 antibody, MBS176325, ICC
ICC: A549 Cell

65,288 Da

tumor protein p63

tumor protein 63; CUSP; transformation-related protein 63; tumor protein p53-competing protein; amplified in squamous cell carcinoma; chronic ulcerative stomatitis protein; keratinocyte transcription factor KET; tumor protein p63 deltaN isoform delta

Tumor protein 63

KET; P63; P73H; P73L; TP73L; p63; CUSP; TP63; p73L??[Similar Products]

P63_HUMAN

This gene encodes a member of the p53 family of transcription factors. An animal model, p63 -/- mice, has been useful in defining the role this protein plays in the development and maintenance of stratified epithelial tissues. p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammary syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8. Both alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different proteins. Many transcripts encoding different proteins have been reported but the biological validity and the full-length nature of these variants have not been determined. [provided by RefSeq, Jul 2008]

p63: Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter. Binds DNA as a homotetramer. Isoform composition of the tetramer may determine transactivation activity. Isoforms Alpha and Gamma interact with HIPK2. Interacts with SSRP1, leading to stimulate coactivator activity. Isoform 1 and isoform 2 interact with WWP1. Interacts with PDS5A. Isoform 5 (via activation domain) interacts with NOC2L. Widely expressed, notably in heart, kidney, placenta, prostate, skeletal muscle, testis and thymus, although the precise isoform varies according to tissue type. Progenitor cell layers of skin, breast, eye and prostate express high levels of DeltaN-type isoforms. Isoform 10 is predominantly expressed in skin squamous cell carcinomas, but not in normal skin tissues. Belongs to the p53 family. 12 isoforms of the human protein are produced by alternative promoter.

Protein type: Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 3q28

Cellular Component: nucleoplasm; transcription factor complex; rough endoplasmic reticulum; dendrite; nuclear chromatin; cytoplasm; cytosol; chromatin; nucleus

Molecular Function: identical protein binding; protein binding; DNA binding; p53 binding; sequence-specific DNA binding; metal ion binding; double-stranded DNA binding; WW domain binding; damaged DNA binding; chromatin binding; transcription factor activity

Biological Process: G1 DNA damage checkpoint; ectoderm and mesoderm interaction; apoptosis; positive regulation of transcription, DNA-dependent; cloacal septation; epidermal cell division; negative regulation of transcription from RNA polymerase II promoter; regulation of caspase activity; protein homotetramerization; polarized epithelial cell differentiation; smooth muscle development; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; sympathetic nervous system development; regulation of neuron apoptosis; positive regulation of mesenchymal cell proliferation; response to gamma radiation; epithelial cell development; establishment of planar polarity; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; female genitalia morphogenesis; skeletal development; proximal/distal pattern formation; positive regulation of Notch signaling pathway; embryonic limb morphogenesis; response to X-ray; regulation of epidermal cell division; Notch signaling pathway; hair follicle morphogenesis; transcription, DNA-dependent; urinary bladder development; negative regulation of keratinocyte differentiation; multicellular organismal aging; keratinocyte proliferation; replicative cell aging; odontogenesis of dentine-containing teeth; keratinocyte differentiation; chromatin remodeling; positive regulation of osteoblast differentiation; neuron apoptosis; positive regulation of transcription from RNA polymerase II promoter; spermatogenesis; negative regulation of transcription, DNA-dependent; response to DNA damage stimulus; negative regulation of apoptosis

Disease: Ankyloblepharon-ectodermal Defects-cleft Lip/palate; Rapp-hodgkin Syndrome; Adult Syndrome; Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/palate Syndrome 3; Split-hand/foot Malformation 4; Limb-mammary Syndrome

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