Full Product Name
AAT Antibody
Product Synonym Names
PI; A1A; AAT; PI1; A1AT; SERPINA1
Product Gene Name
anti-AAT antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P01009
Species Reactivity
Human, Mouse
Form/Format
Ascitic fluid containing 0.03% sodium azide.
Immunogen
Purified recombinant fragment of human AAT expressed in E. Coli.
Preparation and Storage
Store at 4 degree C, for long term storage, store at-20 degree C
Other Notes
Small volumes of anti-AAT antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-AAT antibody
AAT, also known as SERPINA1; serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1. It is secreted and is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Severe Serpin A1 deficiency leads to several clinical complications such as pulmonary emphysema, juvenile hepatisis, cirrhosis and hepatocellular carcinoma.
Product Categories/Family for anti-AAT antibody
Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
Applications Tested/Suitable for anti-AAT antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-AAT antibody
WB: 1:500-1:2000
ELISA: 1:10000
Western Blot (WB) of anti-AAT antibody
Figure 1. Western blot analysis using AAT mouse mAb against human plasma (1) and NIH/3T3 cell lysate (2).
NCBI/Uniprot data below describe general gene information for AAT. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000286.3
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NCBI GenBank Nucleotide #
NM_000295.4
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UniProt Primary Accession #
P01009
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UniProt Secondary Accession #
Q0PVP5; Q13672; Q53XB8; Q5U0M1; Q7M4R2; Q86U18; Q86U19; Q96BF9; Q96ES1; A6PX14; B2RDQ8[Other Products]
UniProt Related Accession #
P01009[Other Products]
NCBI Official Full Name
alpha-1-antitrypsin
NCBI Official Synonym Full Names
serpin family A member 1
NCBI Official Symbol
SERPINA1??[Similar Products]
NCBI Official Synonym Symbols
PI; A1A; AAT; PI1; A1AT; nNIF; PRO2275; alpha1AT
??[Similar Products]
NCBI Protein Information
alpha-1-antitrypsin
UniProt Protein Name
Alpha-1-antitrypsin
UniProt Synonym Protein Names
Alpha-1 protease inhibitor; Alpha-1-antiproteinase; Serpin A1
Protein Family
Leucyl/phenylalanyl-tRNA--protein transferase
UniProt Gene Name
SERPINA1??[Similar Products]
UniProt Synonym Gene Names
AAT; PI; SPAAT??[Similar Products]
NCBI Summary for AAT
The protein encoded by this gene is secreted and is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Defects in this gene can cause emphysema or liver disease. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for AAT
Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin.
Research Articles on AAT
1. A1AT polymorphisms may be associated with human retrovirus infections in an ethnically mixed population from the Amazon region of Brazil.
Precautions
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Disclaimer
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