Product Name
Alpha 1 Antichymotrypsin (SERPINA1), Polyclonal Antibody
Full Product Name
Alpha 1 Antichymotrypsin antibody
Product Synonym Names
Polyclonal Alpha 1 Antichymotrypsin; Anti-Alpha 1 Antichymotrypsin; ACT; Alpha-1-antichymotrypsin; Cell growth-inhibiting gene 24/25 protein; GIG24; GIG25; growth-inhibiting protein 24; growth-inhibiting protein 25; MGC88254; serine (or cysteine) proteinase inhibitor clade A member 3; Serpin A3; Serpin peptidase inhibitor clade A member 3
Product Gene Name
anti-SERPINA1 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P01009
Form/Format
Supplied as raw serum with 0.09% NaN3.
Biological Significance
Although its physiological function is unclear, Alpha 1 Antichymotrypsin can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2. Belongs to the serpin family.
Immunogen
Alpha 1 Antichymotrypsin antibody was raised in goat using alpha-1-antichymotrypsin isolated from normal human plasma as the immunogen.
Preparation and Storage
Aliquot and store at -20 degree C. Avoid repeated freeze/thaw Cycles
Other Notes
Small volumes of anti-SERPINA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-SERPINA1 antibody
Goat polyclonal Human Alpha 1 Antichymotrypsin antibody
Product Categories/Family for anti-SERPINA1 antibody
Immunology
Applications Tested/Suitable for anti-SERPINA1 antibody
User optimized
NCBI/Uniprot data below describe general gene information for SERPINA1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001121179.1
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NCBI GenBank Nucleotide #
NM_001127707.1
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UniProt Primary Accession #
P01009
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UniProt Secondary Accession #
Q0PVP5; Q13672; Q53XB8; Q5U0M1; Q7M4R2; Q86U18; Q86U19; Q96BF9; Q96ES1; A6PX14; B2RDQ8[Other Products]
UniProt Related Accession #
P01009[Other Products]
Molecular Weight
34,755 Da[Similar Products]
NCBI Official Full Name
alpha-1-antitrypsin
NCBI Official Synonym Full Names
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
NCBI Official Symbol
SERPINA1??[Similar Products]
NCBI Official Synonym Symbols
PI; A1A; AAT; PI1; A1AT; PRO2275; alpha1AT
??[Similar Products]
NCBI Protein Information
alpha-1-antitrypsin
UniProt Protein Name
Alpha-1-antitrypsin
UniProt Synonym Protein Names
Alpha-1 protease inhibitor; Alpha-1-antiproteinase; Serpin A1
Protein Family
Alpha-1-antitrypsin
UniProt Gene Name
SERPINA1??[Similar Products]
UniProt Synonym Gene Names
AAT; PI; SPAAT??[Similar Products]
UniProt Entry Name
A1AT_HUMAN
NCBI Summary for SERPINA1
The protein encoded by this gene is secreted and is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Defects in this gene can cause emphysema or liver disease. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for SERPINA1
SERPINA1: Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin. Defects in SERPINA1 are the cause of alpha-1-antitrypsin deficiency (A1ATD). A disorder whose most common manifestation is emphysema, which becomes evident by the third to fourth decade. A less common manifestation of the deficiency is liver disease, which occurs in children and *****s, and may result in cirrhosis and liver failure. Environmental factors, particularly cigarette smoking, greatly increase the risk of emphysema at an earlier age. Belongs to the serpin family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted, signal peptide; Secreted; Inhibitor
Chromosomal Location of Human Ortholog: 14q32.1
Cellular Component: Golgi apparatus; extracellular space; proteinaceous extracellular matrix; endoplasmic reticulum; extracellular region
Molecular Function: serine-type endopeptidase inhibitor activity; identical protein binding; protein binding; protease binding; glycoprotein binding
Biological Process: platelet activation; response to chromate; platelet degranulation; response to triglyceride; response to cytokine stimulus; response to lead ion; acute-phase response; response to hypoxia; response to methanol; response to lipopolysaccharide; blood coagulation; response to estradiol stimulus
Disease: Alpha-1-antitrypsin Deficiency; Pulmonary Disease, Chronic Obstructive
Research Articles on SERPINA1
1. alpha-1-antitrypsin as substrate of HTRA1 synthetic
Precautions
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Disclaimer
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