Full Product Name
Anti-TSHR Antibody
Product Gene Name
anti-TSHR antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P16473
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Affinity Purification
Concentration
1mg/ml (lot specific)
Immunogen
Recombinant protein of human TSHR
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Preparation and Storage
Store at -20 degree C. Avoid freeze/thaw cycles.
Other Notes
Small volumes of anti-TSHR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-TSHR antibody
The protein encoded by this gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase.
Applications Tested/Suitable for anti-TSHR antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-TSHR antibody
WB: 1:500-1:2000
IHC: 1:50-1:200
NCBI/Uniprot data below describe general gene information for TSHR. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001136098.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001142626.2
[Other Products]
UniProt Primary Accession #
P16473
[Other Products]
UniProt Secondary Accession #
Q16503; Q8TB90; Q96GT6; Q9P1V4; Q9ULA3; Q9UPH3; A0PJU7; F5GYU5; G3V2A9[Other Products]
UniProt Related Accession #
P16473[Other Products]
Molecular Weight
30,800 Da
NCBI Official Full Name
thyrotropin receptor isoform 3
NCBI Official Synonym Full Names
thyroid stimulating hormone receptor
NCBI Official Symbol
TSHR??[Similar Products]
NCBI Official Synonym Symbols
LGR3; CHNG1; hTSHR-I
??[Similar Products]
NCBI Protein Information
thyrotropin receptor
UniProt Protein Name
Thyrotropin receptor
UniProt Synonym Protein Names
Thyroid-stimulating hormone receptor; TSH-R
Protein Family
Thyrotropin receptor
UniProt Gene Name
TSHR??[Similar Products]
UniProt Synonym Gene Names
LGR3; TSH-R??[Similar Products]
NCBI Summary for TSHR
The protein encoded by this gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
UniProt Comments for TSHR
Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin (PubMed:11847099, PubMed:12045258). Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin (PubMed:12045258). The activity of this receptor is mediated by G proteins which activate adenylate cyclase (PubMed:11847099). Plays a central role in controlling thyroid cell metabolism ().
Research Articles on TSHR
1. Overexpression of TSHR was found in a great majority of hepatocellular carcinomatissues and associated with unfavorable prognosis
Precautions
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Disclaimer
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