Anti -DMC (Dendritic cell and Monocyte Chemokine-like Protein, VEGF Co-regulated Chemokine 1, VCC1) (Biotin)

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 18; NC_000018.9 (46567846..46987172, complement). Location: 18q21.1

Polyclonal

IgG

Sheep

Recognizes mouse DMC. 5% cross-reactivity with rhDMC

Affinity Purified
Purified by mouse DMC affinity chromatography.

Supplied as a lyophilized powder from PBS with BSA. Reconstitute with 100ul sterile TBS, pH 7.3, 0.1% BSA. Labeled with Biotin.

-20 degree C

Small volumes of anti-DYM antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Dendritic cell- and Monocyte-attracting Chemokine-like protein (DMC), also known as VEGF-induced cytokine (VCC-1), is a secreted molecule that is closely related to CXCL8/IL-8 and CXCL14/BRAK. DMC is constitutively produced by airway and intestinal epithelium and induces the chemotaxis of monocytes and dendritic cells. It is strongly upregulated in proliferating

Antibodies; Abs to Growth Factors, Cytokines

Western Blot (WB)

Suitable for use in Western blot., , Recommended Dilutions:, Western Blot: 0.01-0.2ug/ml with the appropriate secondary reagents to detect mouse DMC. The detection limit for rmDMC is approximately 2 ng/lane under non-reducing and reducing, conditions. In this format, this antibody shows approximately 5% cross-reactivity with rhDMC., , Storage and Stability:, Lyophilized powder may be stored at 4 degree C for short-term only. Reconstitute to nominal volume by adding sterile 40-50% glycerol, aliquot and store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

75,935 Da[Similar Products]

dymeclin

dymeclin; dyggve-Melchior-Clausen syndrome protein

Dymeclin

DYM_HUMAN

This gene encodes a protein which is necessary for normal skeletal development and brain function. Mutations in this gene are associated with two types of recessive osteochondrodysplasia, Dyggve-Melchior-Clausen (DMC) dysplasia and Smith-McCort (SMC) dysplasia, which involve both skeletal defects and mental retardation. [provided by RefSeq, Jul 2008]

DYM: Necessary for correct organization of Golgi apparatus. Involved in bone development. Defects in DYM are the cause of Dyggve-Melchior-Clausen syndrome (DMC). DMC is a rare autosomal recessive disorder characterized by short trunk dwarfism, microcephaly and psychomotor retardation. Electron microscopic study of cutaneous cells of affected patients shows dilated rough endoplasmic reticulum, enlarged and aberrant vacuoles and numerous vesicles. DMC is progressive. Defects in DYM are the cause of Smith-McCort dysplasia (SMC). SMC is a rare autosomal recessive osteochondrodysplasia characterized by short limbs and trunk with barrel-shaped chest. The radiographic phenotype includes platyspondyly, generalized abnormalities of the epiphyses and metaphyses, and a distinctive lacy appearance of the iliac crest, features identical to those of Dyggve-Melchior-Clausen syndrome. Belongs to the dymeclin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 18q21.1

Cellular Component: Golgi apparatus; cytoplasm

Molecular Function: protein binding; enzyme binding

Biological Process: Golgi organization and biogenesis

Disease: Dyggve-melchior-clausen Disease; Smith-mccort Dysplasia 1

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