Anti -DMC (Dendritic cell and Monocyte Chemokine-like Protein, VEGF Co-regulated Chemokine 1, VCC1)

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 18; NC_000018.9 (46567846..46987172, complement). Location: 18q21.1

Monoclonal

IgG2b

9H112

Rat

Recognizes mouse DMC.

Affinity Purified
Purified by Protein G affinity chromatography.

Supplied as a lyophilized powder in 0.2um sterile-filtered solution, PBS, 5% trehalose. Reconstitute with 40-50% glycerol, PBS.

Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile 40-50% glycerol, PBS.. Aliquot and store at -20 degree C. Reconstituted product is stable for 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Small volumes of anti-DYM antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Mouse DMC (dendritic cell and monocyte chemokine-like protein; also VCC-1) is a secreted 11kD member of the CXC chemokine family. It is constitutively produced in lung, induced in endothelium by VEGF, and chemoattracts monocytes and dendritic cells. Mouse DMC is 97aa in length. It contains six cysteines with no potential N-linked glycosylation sites. Over aa31-119, mouse MDC shares 83% and 70% aa identity with rat and human MDC, respectively.

Antibodies; Abs to Proteins

Western Blot (WB)

Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 0.5-1.0ug/ml
Western Blot: 2ug/ml

75,935 Da[Similar Products]

dymeclin

dymeclin; dyggve-Melchior-Clausen syndrome protein

Dymeclin

DYM_HUMAN

This gene encodes a protein which is necessary for normal skeletal development and brain function. Mutations in this gene are associated with two types of recessive osteochondrodysplasia, Dyggve-Melchior-Clausen (DMC) dysplasia and Smith-McCort (SMC) dysplasia, which involve both skeletal defects and mental retardation. [provided by RefSeq, Jul 2008]

DYM: Necessary for correct organization of Golgi apparatus. Involved in bone development. Defects in DYM are the cause of Dyggve-Melchior-Clausen syndrome (DMC). DMC is a rare autosomal recessive disorder characterized by short trunk dwarfism, microcephaly and psychomotor retardation. Electron microscopic study of cutaneous cells of affected patients shows dilated rough endoplasmic reticulum, enlarged and aberrant vacuoles and numerous vesicles. DMC is progressive. Defects in DYM are the cause of Smith-McCort dysplasia (SMC). SMC is a rare autosomal recessive osteochondrodysplasia characterized by short limbs and trunk with barrel-shaped chest. The radiographic phenotype includes platyspondyly, generalized abnormalities of the epiphyses and metaphyses, and a distinctive lacy appearance of the iliac crest, features identical to those of Dyggve-Melchior-Clausen syndrome. Belongs to the dymeclin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 18q21.1

Cellular Component: Golgi apparatus; cytoplasm

Molecular Function: protein binding; enzyme binding

Biological Process: Golgi organization and biogenesis

Disease: Dyggve-melchior-clausen Disease; Smith-mccort Dysplasia 1

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