Product Name
DYM, cDNA Clone
Full Product Name
DYM cDNA Clone
Product Gene Name
DYM cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atgggatcga atagcagcag aatcggcgat cttcctaaaa atgagtactt gaaaaagtta tcaggcacgg aatctatctc tgagaatgac ccgttctgga atcagcttct ctcattttct ttccctgcac caactagcag tagtgagttg aaactcttgg aggaagcaac catttcagtc tgcaggtcat tagttgaaaa caatcctcga acaggaaatc ttggtgcact aattaaggtc ttcctttcta gaaccaaaga actaaaactt tcagcagaat gtcagaacca catcttcatt tggcagacac acaatgcttt gtttattatt tgctgtttgc tgaaagtgtt catctgtcag atgtcagagg aggaattaca acttcatttt acttatgaag aaaaatctcc tggcaattac agttctgact cagaagatct tttggaagaa ttgctgtgct gtttgatgca gttgatcact gatattccac tcttagatat tacatatgaa atatcagtag aagctatatc aacaatggtt gttttccttt cctgccaact cttccacaaa gaagttttgc gacagagcat cagccacaag tatttgatgc gaggtccatg tcttccatac accagcaaac ttgtgaagac cttattatat aactttatca gacaagaaaa gccacctcct ccaggggccc atgttttccc tcagcagtcg gatgggggag gactgcttta tggacttgca tcaggagtag caacaggact ctggactgtc ttcacactag gtggtgtggg cagcaaagcg gctgcctctc cagagctttc ttcccctctg gccaaccaga gtctcctgct tctgctggtg ttggccaatc tgacagatgc ctcagatgcg ccaaacccct acagacaagc cattatgtcc ttcaagaaca cacaagatag cagtcctttc ccctcatcaa ttccacatgc cttccagatc aactttaata gtttgtacac agctctttgt gaacagcaga catctgatca agcaactctc ctcttgtata ccttgctcca tcaaaatagt aatattagaa catacatgtt ggctcgcaca gatatggaaa atcttgtttt accaattctt gagattctgt atcatgttga agaaaggaat tcacaccatg tgtatatggc ccttataata ttgttgatcc ttacggaaga ttatggcttc aacagatcca ttcatgaagt gatactaaaa aatattactt ggtattcaga acgagtttta actgaaatct ccttggggag tctcctgatc ctggtggtaa taagaaccat tcaatacaac atgactagga cacgagacaa gtaccttcac acaaattgtt tggcagcttt agcaaatatg tcggcacagt ttcgttctct ccatcagtat gctgcccaga ggatcatcag tttattttct ttgctgtcta aaaaacacaa caaagttctg gaacaagcca cacagtcctt gagaggttcg ctgagttcta atgatgttcc tctaccagat tatgcacaag acctaaatgt cattgaagaa gtgattcgaa tgatgttaga gatcatcaac tcctgcctga caaattccct tcaccacaac ccaaacttgg tatacgccct gctttacaaa cgcgatctct ttgaacaatt tcgaactcat ccttcatttc aggatataat gcaaaatatt gatctggtga tctccttctt tagctcaagg ttgctgcaag ctggagctga gctgtcagtg gaacgggtcc tggaaatcat taagcaaggc gtcgttgcgc tgcccaaaga cagactgaag aaatttccag aattgaaatt caaatatgtg gaagaggagc agcccgagga gttttttatc ccctatgtct ggtctcttgt ctacaactca gcagtcggcc tgtactggaa tccacaggac atccagctgt tcaccatgga ttccgactga
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of DYM cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for DYM. It may not necessarily be applicable to this product.
NCBI Accession #
BC064394
[Other Products]
UniProt Secondary Accession #
Q3ZTS8; Q6P2P5; Q8N2M0; Q9BVE9; Q9NPU7; A8K5I8; B2RCF9; B4DKI7[Other Products]
UniProt Related Accession #
Q7RTS9[Other Products]
Molecular Weight
54,425 Da
NCBI Official Full Name
Homo sapiens dymeclin, mRNA
NCBI Official Synonym Full Names
dymeclin
NCBI Official Symbol
DYM??[Similar Products]
NCBI Official Synonym Symbols
DMC; SMC
??[Similar Products]
NCBI Protein Information
dymeclin
UniProt Protein Name
Dymeclin
UniProt Synonym Protein Names
Dyggve-Melchior-Clausen syndrome protein
UniProt Gene Name
DYM??[Similar Products]
UniProt Entry Name
DYM_HUMAN
NCBI Summary for DYM
This gene encodes a protein which is necessary for normal skeletal development and brain function. Mutations in this gene are associated with two types of recessive osteochondrodysplasia, Dyggve-Melchior-Clausen (DMC) dysplasia and Smith-McCort (SMC) dysplasia, which involve both skeletal defects and mental retardation. [provided by RefSeq, Jul 2008]
UniProt Comments for DYM
DYM: Necessary for correct organization of Golgi apparatus. Involved in bone development. Defects in DYM are the cause of Dyggve-Melchior-Clausen syndrome (DMC). DMC is a rare autosomal recessive disorder characterized by short trunk dwarfism, microcephaly and psychomotor retardation. Electron microscopic study of cutaneous cells of affected patients shows dilated rough endoplasmic reticulum, enlarged and aberrant vacuoles and numerous vesicles. DMC is progressive. Defects in DYM are the cause of Smith-McCort dysplasia (SMC). SMC is a rare autosomal recessive osteochondrodysplasia characterized by short limbs and trunk with barrel-shaped chest. The radiographic phenotype includes platyspondyly, generalized abnormalities of the epiphyses and metaphyses, and a distinctive lacy appearance of the iliac crest, features identical to those of Dyggve-Melchior-Clausen syndrome. Belongs to the dymeclin family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 18q21.1
Cellular Component: cytoplasm; Golgi apparatus
Molecular Function: enzyme binding; protein binding
Biological Process: Golgi organization and biogenesis
Disease: Dyggve-melchior-clausen Disease; Smith-mccort Dysplasia 1
Research Articles on DYM
1. Dymeclin is crucial for proper myelination and anterograde neuronal trafficking, two processes that are highly active during postnatal brain maturation.
Precautions
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Disclaimer
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