Product Name
TFAP2B, Polyclonal Antibody
Full Product Name
TFAP2B Antibody
Product Synonym Names
Transcription factor AP-2-beta; AP2-beta; Activating enhancer-binding protein 2-beta; TFAP2B
Product Gene Name
anti-TFAP2B antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q92481
Purity/Purification
>95%, Protein G purified
Immunogen
Recombinant Human Transcription factor AP-2-beta protein (111-208AA)
Conjugation
Non-conjugated
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Preparation and Storage
Upon receipt, store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-TFAP2B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-TFAP2B antibody
Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important
biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-beta appears to be required for normal face and limb development and for proper terminal differentiation and function of renal tubular epithelia.
Product Categories/Family for anti-TFAP2B antibody
Epigenetics and Nuclear Signaling; Cell biology
Applications Tested/Suitable for anti-TFAP2B antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-TFAP2B antibody
WB: 1:500-1:5000
Western Blot (WB) of anti-TFAP2B antibody
Western Blot
Positive WB detected in: Hela whole cell lysate, MCF-7 whole cell lysate
All lanes: TFAP2B antibody at 3.2ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 51, 52 KDa
Observed band size: 51, 52 KDa
NCBI/Uniprot data below describe general gene information for TFAP2B. It may not necessarily be applicable to this product.
NCBI Accession #
NP_003212.2
[Other Products]
NCBI GenBank Nucleotide #
NM_003221.3
[Other Products]
UniProt Primary Accession #
Q92481
[Other Products]
UniProt Secondary Accession #
Q5JYX6; Q9NQ63; Q9NU99; Q9UJI7; Q9Y214; Q9Y3K3[Other Products]
UniProt Related Accession #
Q92481[Other Products]
Molecular Weight
51,524 Da
NCBI Official Full Name
transcription factor AP-2-beta
NCBI Official Synonym Full Names
transcription factor AP-2 beta
NCBI Official Symbol
TFAP2B??[Similar Products]
NCBI Official Synonym Symbols
PDA2; AP-2B; AP2-B
??[Similar Products]
NCBI Protein Information
transcription factor AP-2-beta
UniProt Protein Name
Transcription factor AP-2-beta
UniProt Synonym Protein Names
Activating enhancer-binding protein 2-beta
Protein Family
Transcription factor
UniProt Gene Name
TFAP2B??[Similar Products]
UniProt Synonym Gene Names
AP2-beta??[Similar Products]
NCBI Summary for TFAP2B
This gene encodes a member of the AP-2 family of transcription factors. AP-2 proteins form homo- or hetero-dimers with other AP-2 family members and bind specific DNA sequences. They are thought to stimulate cell proliferation and suppress terminal differentiation of specific cell types during embryonic development. Specific AP-2 family members differ in their expression patterns and binding affinity for different promoters. This protein functions as both a transcriptional activator and repressor. Mutations in this gene result in autosomal dominant Char syndrome, suggesting that this gene functions in the differentiation of neural crest cell derivatives. [provided by RefSeq, Jul 2008]
UniProt Comments for TFAP2B
Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-beta appears to be required for normal face and limb development and for proper terminal differentiation and function of renal tubular epithelia.
Research Articles on TFAP2B
1. AP-2 beta and beta-catenin interact both in vitro through GST pull-down assays and in vivo by co-immunoprecipitation. We further identified the interaction regions to the DNA-binding domain of AP-2 beta and the 1-9 Armadillo repeats of beta-catenin.
Precautions
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Disclaimer
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