Anti -Nav1.5 (SKM2, Scn5a, CDCD2, CMD1E, CMPD2, HB1, HB2, HH1, IVF, LQT3, Sodium Channel Protein Cardiac Muscle alpha-subunit, Sodium Channel Protein Type 5 Subunit alpha, SCN5A, Sodium Channel Protein Type V alpha Subunit, SSS1, Voltage-gated Sodium Channel al

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 3; NC_000003.11 (38589553..38691164, complement). Location: 3p21

Polyclonal

IgG

Rabbit

Recognizes rat NaV1.5 (SKM2, Scn5a). Species Sequence Homology: mouse-100%, human-17/19.

Affinity Purified
Purified by immunoaffinity chromatography.

Supplied as a liquid in PBS, pH 7.4, 1% BSA, 5% sucrose, 0.025% sodium azide before the addition of glycerol to 40%.

May be stored at 4 degree C for short-term only. For long-term storage, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer

Small volumes of anti-SCN5A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

The protein encoded by this gene is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. The encoded protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Defects in this gene are a cause of long QT syndrome type 3 (LQT3), an autosomal dominant cardiac disease. Alternative splicing results in two transcript variants encoding separate isoforms which differ by a single amino acid. Mutation nomenclature has been assigned with respect to the longer isoform.

Antibodies; Abs to Ion Channel

Western Blot (WB)

Suitable for use in Western Blot.
Dilution: Western Blot: 1:100-1:200. Rat heart membranes.

12,445 Da[Similar Products]

sodium channel, voltage-gated, type V, alpha subunit

sodium channel protein type 5 subunit alpha; OTTHUMP00000209279; OTTHUMP00000209280; OTTHUMP00000209281; OTTHUMP00000209282; OTTHUMP00000209283; OTTHUMP00000209284; OTTHUMP00000226268; cardiac sodium channel alpha subunit; sodium channel protein type V alpha subunit; sodium channel protein type V subunit alpha; voltage-gated sodium channel subunit alpha Nav1.5; sodium channel protein cardiac muscle subunit alpha; cardiac tetrodotoxin-insensitive voltage-dependent sodium channel alpha subunit

Nav1.5

Q8WWN6_HUMAN

The protein encoded by this gene is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. This protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Defects in this gene are a cause of long QT syndrome type 3 (LQT3), an autosomal dominant cardiac disease. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq]

SCN5A: an integral membrane protein and a voltage-gated sodium channel subunit. Mediates the voltage-dependent sodium ion permeability of excitable membranes. This protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant Na(+) channel isoform. Intracellular calcium levels regulate channel inactivation. Interacts with the PDZ domain of the syntrophin SNTA1, SNTB1 and SNTB2. Interacts with NEDD4, NEDD4L, WWP2 and GPD1L. Defects in this protein are a cause of long QT syndrome type 3 (LQT3). Belongs to the sodium channel (TC 1.A.1.10) family, Nav1.5/SCN5A subfamily. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Channel, sodium; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 3p21

Cellular Component: voltage-gated sodium channel complex; cell surface; endoplasmic reticulum; T-tubule; plasma membrane; integral to membrane; caveola; sarcolemma; lateral plasma membrane

Molecular Function: calmodulin binding; protein binding; enzyme binding; fibroblast growth factor binding; ubiquitin protein ligase binding; voltage-gated sodium channel activity; ankyrin binding; nitric-oxide synthase binding; protein kinase binding

Biological Process: membrane depolarization; axon guidance; telencephalon development; regulation of heart rate; sodium ion transport; generation of action potential; cerebellum development; positive regulation of action potential; response to denervation involved in regulation of muscle adaptation; positive regulation of epithelial cell proliferation; odontogenesis of dentine-containing teeth; cardiac muscle contraction

Disease: Brugada Syndrome 1; Sudden Infant Death Syndrome; Ventricular Fibrillation During Myocardial Infarction, Susceptibility To; Sick Sinus Syndrome 1, Autosomal Recessive; Progressive Familial Heart Block, Type Ia; Long Qt Syndrome 3; Cardiomyopathy, Dilated, 1e; Atrial Fibrillation, Familial, 10

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