Product Name
SCN1B, Polyclonal Antibody
Popular Item
Full Product Name
SCN1B Antibody
Product Synonym Names
GEFSP1; SCN1B; SCN1B_HUMAN; sodium channel beta 1 subunit; Sodium channel subunit beta 1; Sodium channel subunit beta-1; Sodium channel voltage gated type I beta; Sodium channel voltage gated type I beta subunit
Product Gene Name
anti-SCN1B antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q07699
Species Reactivity
Human, Mouse, Rat
Specificity
SCN1B antibody detects endogenous levels of total SCN1B
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
Form/Format
Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (lot specific)
Immunogen
A synthesized peptide derived from human SCN1B
Subcellular Location
Membrane.
Tissue Specificity
The overall expression of isoforms 1 and 2 is very similar. Isoform 1 is abundantly expressed in skeletal muscle, heart and brain. Isoform 2 is highly expressed in brain and skeletal muscle and present at a very low level in heart, placenta, lung, liver, kidney and pancreas. In brain, isoform 2 is most abundant in the cerebellum, followed by the cerebral cortex and occipital lobe, while isoform 1 levels are higher in the cortex compared to the cerebellum. Isoform 2 is expressed in many regions of the brain, including cerebellar Purkinje cells, cortex pyramidal neurons and many of the neuronal fibers throughout the brain (at protein level). Also detected in dorsal root ganglion, in fibers of the spinal nerve and in cortical neurons and their processes (at protein level).
Predicted Cross Reactivity
Pig, Bovine, Horse, Sheep, Rabbit, Dog
Similarity
Pig (100%), Bovine (100%), Horse (100%), Sheep (100%), Rabbit (100%), Dog (100%)
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available, please inquire.
Other Notes
Small volumes of anti-SCN1B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-SCN1B antibody
Function: Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-1 can modulate multiple alpha subunit isoforms from brain, skeletal muscle, and heart. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons.
Subunit Structure: The voltage-sensitive sodium channel consists of an ion conducting pore forming alpha-subunit regulated by one or more beta-1, beta-2 and beta-3. Beta-1 and beta-3 are non-covalently associated with alpha, while beta-2 is covalently linked by disulfide bonds. Beta-1 or beta-3 subunits associate with NFASC. Associates with SCN10A (By similarity). Interacts with SCN1A (PubMed:15525788, PubMed:17928445). Interacts with SCN8A (PubMed:26900580).
Similarity: Belongs to the sodium channel auxiliary subunit SCN1B (TC 8.A.17) family.
Applications Tested/Suitable for anti-SCN1B antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-SCN1B antibody
WB: 1:1000-3000
Western Blot (WB) of anti-SCN1B antibody
Western blot analysis SCN1B using HepG2 whole cell lysates
NCBI/Uniprot data below describe general gene information for SCN1B. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001028.1
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NCBI GenBank Nucleotide #
NM_001037.4
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UniProt Primary Accession #
Q07699
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UniProt Secondary Accession #
Q5TZZ4; Q6TN97[Other Products]
UniProt Related Accession #
Q07699[Other Products]
Molecular Weight
Observed: 25 kDa
Predicted: 25 kDa
NCBI Official Full Name
sodium channel subunit beta-1 isoform a
NCBI Official Synonym Full Names
sodium voltage-gated channel beta subunit 1
NCBI Official Symbol
SCN1B??[Similar Products]
NCBI Official Synonym Symbols
ATFB13; BRGDA5; EIEE52; GEFSP1
??[Similar Products]
NCBI Protein Information
sodium channel subunit beta-1
UniProt Protein Name
Sodium channel subunit beta-1
Protein Family
Sodium channel
UniProt Gene Name
SCN1B??[Similar Products]
NCBI Summary for SCN1B
Voltage-gated sodium channels are heteromeric proteins that function in the generation and propagation of action potentials in muscle and neuronal cells. They are composed of one alpha and two beta subunits, where the alpha subunit provides channel activity and the beta-1 subunit modulates the kinetics of channel inactivation. This gene encodes a sodium channel beta-1 subunit. Mutations in this gene result in generalized epilepsy with febrile seizures plus, Brugada syndrome 5, and defects in cardiac conduction. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]
UniProt Comments for SCN1B
Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-1 can modulate multiple alpha subunit isoforms from brain, skeletal muscle, and heart. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons.
Research Articles on SCN1B
1. we confirm the recessive inheritance of 2 novel SCN1B mutations in 5 children from 3 families with developmental epileptic encephalopathy. The recessive inheritance and early death in these patients is consistent with the Dravet-like phenotype observed in Scn1b(-/-) mice.
Precautions
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