Full Product Name
SCN1B Antibody
Product Gene Name
anti-SCN1B antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q07699
Other Notes
Small volumes of anti-SCN1B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Western Blot (WB) of anti-SCN1B antibody
Western blot analysis SCN1B using HepG2 whole cell lysates
NCBI/Uniprot data below describe general gene information for SCN1B. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001028.1
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NCBI GenBank Nucleotide #
NM_001037.4
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UniProt Primary Accession #
Q07699
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UniProt Secondary Accession #
Q5TZZ4; Q6TN97[Other Products]
UniProt Related Accession #
Q07699[Other Products]
Molecular Weight
30,440 Da
NCBI Official Full Name
sodium channel subunit beta-1 isoform a
NCBI Official Synonym Full Names
sodium voltage-gated channel beta subunit 1
NCBI Official Symbol
SCN1B??[Similar Products]
NCBI Official Synonym Symbols
ATFB13; BRGDA5; EIEE52; GEFSP1
??[Similar Products]
NCBI Protein Information
sodium channel subunit beta-1
UniProt Protein Name
Sodium channel subunit beta-1
Protein Family
Sodium channel
UniProt Gene Name
SCN1B??[Similar Products]
NCBI Summary for SCN1B
Voltage-gated sodium channels are heteromeric proteins that function in the generation and propagation of action potentials in muscle and neuronal cells. They are composed of one alpha and two beta subunits, where the alpha subunit provides channel activity and the beta-1 subunit modulates the kinetics of channel inactivation. This gene encodes a sodium channel beta-1 subunit. Mutations in this gene result in generalized epilepsy with febrile seizures plus, Brugada syndrome 5, and defects in cardiac conduction. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]
UniProt Comments for SCN1B
Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-1 can modulate multiple alpha subunit isoforms from brain, skeletal muscle, and heart. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons.
Research Articles on SCN1B
1. we confirm the recessive inheritance of 2 novel SCN1B mutations in 5 children from 3 families with developmental epileptic encephalopathy. The recessive inheritance and early death in these patients is consistent with the Dravet-like phenotype observed in Scn1b(-/-) mice.
Precautions
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