Product Name
MFN2, cDNA Clone
Full Product Name
MFN2 cDNA Clone
Product Gene Name
MFN2 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atgtccctgc tcttctctcg atgcaactct atcgtcacag tcaagaaaaa taagagacac atggctgagg tgaatgcatc cccacttaag cactttgtca ctgccaagaa gaagatcaat ggcatttttg agcagctggg ggcctacatc caggagagcg ccaccttcct tgaagacacg tacaggaatg cagaactgga ccccgttacc acagaagaac aggttctgga cgtcaaaggt tacctatcca aagtgagagg catcagtgag gtgctggctc ggaggcacat gaaagtggct ttttttggcc ggacgagcaa tgggaagagc accgtgatca atgccatgct ctgggacaaa gttctgccct ctgggattgg ccacaccacc aattgcttcc tgcgggtaga gggcacagat ggccatgagg cctttctcct taccgagggc tcagaggaaa agaggagtgc caagactgtg aaccagctgg cccatgccct ccaccaggac aagcagctcc atgccggcag cctagtgagt gtgatgtggc ccaactctaa gtgcccactt ctgaaggatg acctcgtttt gatggacagc cctggtattg atgtcaccac agagctggac agctggattg acaagttttg tctggatgct gatgtgtttg tgctggtggc caactcagag tccaccctga tgcagacgga aaagcacttc ttccacaagg tgagtgagcg tctctcccgg ccaaacatct tcatcctgaa caaccgctgg gatgcatctg cctcagagcc cgagtacatg gaggaggtgc ggcggcagca catggagcgt tgtaccagct tcctggtgga tgagctgggc gtggtggatc gatcccaggc cggggaccgc atcttctttg tgtctgctaa ggaggtgctc aacgccagga ttcagaaagc ccagggcatg cctgaaggag ggggcgctct cgcagaaggc tttcaagtga ggatgtttga gtttcagaat tttgagagga gatttgagga gtgcatctcc cagtctgcag tgaagaccaa gtttgagcag cacacggtcc gggccaagca gattgcagag gcggttcgac tcatcatgga ctccctgcac atggcggctc gggagcagca ggtttactgc gaggaaatgc gtgaagagcg gcaagaccga ctgaaattta ttgacaaaca gctggagctc ttggctcaag actataagct gcgaattaag cagattacgg aggaagtgga gaggcaggtg tcgactgcaa tggccgagga gatcaggcgc ctctctgtac tggtggacga ttaccagatg gacttccacc cttctccagt agtcctcaag gtttataaga atgagctgca ccgccacata gaggaaggac tgggtcgaaa catgtctgac cgctgctcca cggccatcac caactccctg cagaccatgc agcaggacat gatagatggc ttgaaacccc tccttcctgt gtctgtgcgg agtcagatag acatgctggt cccacgccag tgcttctccc tcaactatga cctaaactgt gacaagctgt gtgctgactt ccaggaagac attgagttcc atttctctct cggatggacc atgctggtga ataggttcct gggccccaag aacagccgtc gggccttgat gggctacaat gaccaggtcc agcgtcccat ccctctgacg ccagccaacc ccagcatgcc cccactgcca cagggctcgc tcacccagga ggagttcatg gtttccatgg ttaccggcct ggcctccttg acatccagga cctccatggg cattcttgtt gttggaggag tggtgtggaa ggcagtgggc tggcggctca ttgccctctc ctttgggctc tatggcctcc tctacgtcta tgagcgtctg acctggacca ccaaggccaa ggagagggcc ttcaagcgcc agtttgtgga gcatgccagc gagaagctgc agcttgtcat cagctacact ggctccaact gcagccacca agtccagcag gaactgtctg ggacctttgc tcatctgtgt cagcaagttg acgtcacccg ggagaacctg gagcaggaaa ttgccgccat gaacaagaaa attgaggttc ttgactcact tcagagcaaa gcaaagctgc tcaggaataa agccggttgg ttggacagtg agctcaacat gttcacacac cagtacctgc agcccagcag atag
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of MFN2 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for MFN2. It may not necessarily be applicable to this product.
NCBI Accession #
BC017061
[Other Products]
UniProt Secondary Accession #
O95572; Q5JXC3; Q5JXC4; Q9H131; Q9NSX8; A8K1B3[Other Products]
UniProt Related Accession #
O95140[Other Products]
Molecular Weight
50,041 Da
NCBI Official Full Name
Homo sapiens mitofusin 2, mRNA
NCBI Official Synonym Full Names
mitofusin 2
NCBI Official Symbol
MFN2??[Similar Products]
NCBI Official Synonym Symbols
HSG; MARF; CMT2A; CPRP1; CMT2A2; HMSN6A
??[Similar Products]
NCBI Protein Information
mitofusin-2
UniProt Protein Name
Mitofusin-2
UniProt Synonym Protein Names
Transmembrane GTPase MFN2
UniProt Gene Name
MFN2??[Similar Products]
UniProt Synonym Gene Names
CPRP1; KIAA0214??[Similar Products]
UniProt Entry Name
MFN2_HUMAN
NCBI Summary for MFN2
This gene encodes a mitochondrial membrane protein that participates in mitochondrial fusion and contributes to the maintenance and operation of the mitochondrial network. This protein is involved in the regulation of vascular smooth muscle cell proliferation, and it may play a role in the pathophysiology of obesity. Mutations in this gene cause Charcot-Marie-Tooth disease type 2A2, and hereditary motor and sensory neuropathy VI, which are both disorders of the peripheral nervous system. Defects in this gene have also been associated with early-onset stroke. Two transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
UniProt Comments for MFN2
MFN2: Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN2 acts independently of the cytoskeleton. It therefore plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. Overexpression induces the formation of mitochondrial networks. Plays an important role in the regulation of vascular smooth muscle cell proliferation. Defects in MFN2 are the cause of Charcot-Marie-Tooth disease type 2A2 (CMT2A2). CMT2A2 is a form of Charcot-Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathy or CMT1, and primary peripheral axonal neuropathy or CMT2. Neuropathies of the CMT2 group are characterized by signs of axonal regeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy. Defects in MFN2 are the cause of Charcot-Marie-Tooth disease type 6 (CMT6); also referred to as autosomal dominant hereditary motor and sensory neuropathy VI (HMSN6). CMT6 is an autosomal dominant form of axonal CMT associated with optic atrophy. Belongs to the mitofusin family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; EC 3.6.5.-; Mitochondrial; Cytoskeletal; Hydrolase; Membrane protein, multi-pass; Cell cycle regulation
Chromosomal Location of Human Ortholog: 1p36.22
Cellular Component: cytosol; intrinsic to mitochondrial outer membrane; mitochondrial outer membrane; mitochondrion
Molecular Function: protein binding; ubiquitin protein ligase binding
Biological Process: blood coagulation; cell cycle arrest; macroautophagy; mitochondrial fusion; mitochondrial membrane organization and biogenesis; mitochondrion localization; negative regulation of Ras protein signal transduction; negative regulation of smooth muscle cell proliferation; protein targeting to mitochondrion
Disease: Charcot-marie-tooth Disease, Axonal, Type 2a2; Neuropathy, Hereditary Motor And Sensory, Type Vi
Research Articles on MFN2
1. Our findings provide new insight into the mechanism underlying Mitofusin-2 regulation and the potential role of miR-761 in tocellular carcinoma, making it a potential candidate for use in HCC therapy in the future
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Disclaimer
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