Product Name
SCO Cytochrome Oxidase Deficient Homolog 2 (SCO2), Polyclonal Antibody
Full Product Name
SCO Cytochrome Oxidase Deficient Homolog 2 (SCO2, MGC125823, MGC125825)
Product Synonym Names
Anti -SCO Cytochrome Oxidase Deficient Homolog 2 (SCO2, MGC125823, MGC125825)
Product Gene Name
anti-SCO2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 22; NC_000022.10 (50961997..50964868, complement). Location: 22q13.33
3D Structure
ModBase 3D Structure for O43819
Specificity
Recognizes Human SCO Cytochrome Oxidase Deficient Homolog 2 (SCO2). Species Crossreactivity: Human.
Form/Format
Supplied as a liquid in PBS, 0.02% sodium azide.
Immunogen
Synthetic peptide, KLH-conjugated. Epitope: 19 amino acid peptide from near the carboxy terminus of human SCO2.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Other Notes
Small volumes of anti-SCO2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-SCO2 antibody
Antibodies; Abs to Enzymes, Cytochrome
Applications Tested/Suitable for anti-SCO2 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-SCO2 antibody
Suitable for use in Western Blot and Immunohistochemistry.
Dilution: Immunohistochemistry: 2.5ug/ml
NCBI/Uniprot data below describe general gene information for SCO2. It may not necessarily be applicable to this product.
NCBI Accession #
AAI02026.1
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UniProt Primary Accession #
O43819
[Other Products]
UniProt Secondary Accession #
Q3T1B5; Q9UK87[Other Products]
UniProt Related Accession #
O43819[Other Products]
Molecular Weight
29,810 Da[Similar Products]
NCBI Official Full Name
SCO cytochrome oxidase deficient homolog 2 (yeast)
NCBI Official Synonym Full Names
SCO2 cytochrome c oxidase assembly protein
NCBI Official Symbol
SCO2??[Similar Products]
NCBI Official Synonym Symbols
MYP6; SCO1L; CEMCOX1
??[Similar Products]
NCBI Protein Information
protein SCO2 homolog, mitochondrial; cytochrome oxidase deficient homolog 2; SCO cytochrome oxidase deficient homolog 2
UniProt Protein Name
Protein SCO2 homolog, mitochondrial
UniProt Gene Name
SCO2??[Similar Products]
UniProt Entry Name
SCO2_HUMAN
NCBI Summary for SCO2
Cytochrome c oxidase (COX) catalyzes the transfer of electrons from cytochrome c to molecular oxygen, which helps to maintain the proton gradient across the inner mitochondrial membrane that is necessary for aerobic ATP production. Human COX is a multimeric protein complex that requires several assembly factors; this gene encodes one of the COX asembly factors. The encoded protein is a metallochaperone that is involved in the biogenesis of cytochrome c oxidase subunit II. Mutations in this gene are associated with fatal infantile encephalocardiomyopathy. [provided by RefSeq, Dec 2009]
UniProt Comments for SCO2
SCO2: Acts as a copper chaperone, transporting copper to the Cu(A) site on the cytochrome c oxidase subunit II (COX2). Defects in SCO2 are the cause of fatal infantile cardioencephalomyopathy with cytochrome c oxidase deficiency (FIC). This disease is characterized by hypertrophic cardiomyopathy, lactic acidosis, and gliosis. Heart and skeletal muscle show reductions in cytochrome c oxidase (COX) activity, whereas liver and fibroblasts show mild COX deficiencies. Belongs to the SCO1/2 family.
Protein type: Mitochondrial
Chromosomal Location of Human Ortholog: 22q13.33
Cellular Component: nucleoplasm; mitochondrion; myofibril; mitochondrial inner membrane
Molecular Function: copper ion binding
Biological Process: cellular copper ion homeostasis; eye development; in utero embryonic development; respiratory chain complex IV assembly; response to activity; copper ion transport; muscle system process
Disease: Cardioencephalomyopathy, Fatal Infantile, Due To Cytochrome C Oxidase Deficiency 1; Myopia 6
Research Articles on SCO2
1. Exogenous addition of the SCO2 gene to hypoxic cancer cells and hypoxic tumors induces apoptosis.
Precautions
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Disclaimer
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