Product Name
Dymeclin (DYM), Recombinant Protein
Full Product Name
Recombinant Human Dymeclin (DYM)
Product Gene Name
DYM recombinant protein
[Similar Products]
Product Synonym Gene Name
DYM[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
2-669aa, Full Length of Mature Protein
Sequence
GSNSSRIGDL PKNEYLKKLS GTESISENDP FWNQLLSFSF PAPTSSSELK LLEEATISVC RSLVENNPRT GNLGALIKVF LSRTKELKLS AECQNHIFIW QTHNALFIIC CLLKVFICQM SEEELQLHFT YEEKSPGNYS SDSEDLLEEL LCCLMQLITD IPLLDITYEI SVEAISTMVV FLSCQLFHKE VLRQSISHKY LMRGPCLPYT SKLVKTLLYN FIRQEKPPPP GAHVFPQQSD GGGLLYGLAS GVATGLWTVF TLGGVGSKAA ASPELSSPLA NQSLLLLLVL ANLTDASDAP NPYRQAIMSF KNTQDSSPFP SSIPHAFQIN FNSLYTALCE QQTSDQATLL LYTLLHQNSN IRTYMLARTD MENLVLPILE ILYHVEERNS HHVYMALIIL LILTEDDGFN RSIHEVILKN ITWYSERVLT EISLGSLLIL VVIRTIQYNM TRTRDKYLHT NCLAALANMS AQFRSLHQYA AQRIISLFSL LSKKHNKVLE QATQSLRGSL SSNDVPLPDY AQDLNVIEEV IRMMLEIINS CLTNSLHHNP NLVYALLYKR DLFEQFRTHP SFQDIMQNID LVISFFSSRL LQAGAELSVE RVLEIIKQGV VALPKDRLKK FPELKFKYVE EEQPEEFFIP YVWSLVYNSA VGLYWNPQDI QLFTMDSD
3D Structure
ModBase 3D Structure for Q7RTS9
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of DYM recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
DYM recombinant protein
This gene encodes a protein which is necessary for normal skeletal development and brain function. Mutations in this gene are associated with two types of recessive osteochondrodysplasia, Dyggve-Melchior-Clausen (DMC) dysplasia and Smith-McCort (SMC) dysplasia, which involve both skeletal defects and mental retardation.
NCBI/Uniprot data below describe general gene information for DYM. It may not necessarily be applicable to this product.
NCBI Accession #
NP_060123.3
[Other Products]
NCBI GenBank Nucleotide #
NM_017653.4
[Other Products]
UniProt Primary Accession #
Q7RTS9
[Other Products]
UniProt Secondary Accession #
Q3ZTS8; Q6P2P5; Q8N2M0; Q9BVE9; Q9NPU7; A8K5I8; B2RCF9; B4DKI7[Other Products]
UniProt Related Accession #
Q7RTS9[Other Products]
Molecular Weight
54,425 Da
NCBI Official Full Name
dymeclin isoform 1
NCBI Official Synonym Full Names
dymeclin
NCBI Official Symbol
DYM??[Similar Products]
NCBI Official Synonym Symbols
DMC; SMC
??[Similar Products]
NCBI Protein Information
dymeclin
UniProt Protein Name
Dymeclin
UniProt Synonym Protein Names
Dyggve-Melchior-Clausen syndrome protein
UniProt Gene Name
DYM??[Similar Products]
NCBI Summary for DYM
This gene encodes a protein which regulates Golgi-associated secretory pathways that are essential to endochondral bone formation during early development. This gene is also believed to play a role in early brain development. This gene is widely expressed in embryos and is particularly abundant in chodrocytes and brain tissues. It encodes a peripheral membrane protein which shuttles between the cytosol and Golgi complex. Mutations in this gene are associated with two types of recessive osteochondrodysplasia: Dyggve-Melchior-Clausen (DMC) dysplasia and Smith-McCort (SMC) dysplasia. [provided by RefSeq, Jun 2017]
UniProt Comments for DYM
Necessary for correct organization of Golgi apparatus. Involved in bone development.
Research Articles on DYM
1. Dymeclin is crucial for proper myelination and anterograde neuronal trafficking, two processes that are highly active during postnatal brain maturation.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
