ABCG2 (ATP-binding Cassette (ABC) Transporter 2)

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 4; NC_000004.11 (89011416..89080011, complement). Location: 4q22

Polyclonal

IgG

Host: Rabbit
Source: Human

Human control peptide is 100% conserved in Chimp, and 85% in monkey ABCG2, and only 42% in rat and 28% in mouse ABCG2.

Purified by immunoaffinity chromatography.

Affinity Purified
Supplied as a liquid in PBS, pH 7.2, 0.1% sodium azide, before the addition of glycerol to 40%.

~1mg/ml (lot specific)

May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Small volumes of anti-ABCG2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

The ATP binding cassette (ABC) superfamily of membrane transporters is one of the largest protein classes known, and counts for numerous proteins involved in trafficking of biological molecules across membranes, host-defense mechanism to xenobiotics. The first known members were P-glycoprotein (P-gp) and multidrug resistant protein (MRP), cause multidrug resistance when transfected into drug-sensitive cells. In addition, increasing numbers of ABC proteins have recently been identified. The human ABCG1 (ABC, subfamily G, member 1) gene encodes a member of ABC superfamily that mediates the ATP-dependent translocation of variety of amphiphilic and lipophilic molecules. ABCG proteins were able to transport substances across cellular membranes and against concentration gradient they require an input of energy, which requires the hydrolysis of ATP, directly or indirectly.

Abs to Transporters

ELISA, Western Blot

Suitable for use in Western Blot and ELISA. Other applications not tested.
Dilution: Western Blot: 1-10ug/ml using ECL technique.
ELISA: Control peptide can be used to coat ELISA plates at 1ug/ml and detected with antibodies (0.5-1ug/ml).
Optimal dilution determined by the researcher.

72,314 Da

ATP-binding cassette, sub-family G (WHITE), member 2

ATP-binding cassette sub-family G member 2; ABC transporter; OTTHUMP00000161176; OTTHUMP00000219514; placenta specific MDR protein; mitoxantrone resistance protein; breast cancer resistance protein; ATP-binding cassette transporter G2; mitoxantrone resistance-associated protein; placenta-specific ATP-binding cassette transporter

ATP-binding cassette sub-family G member 2

ABCP; BCRP; BCRP1; MXR??[Similar Products]

ABCG2_HUMAN

??Csilla Ozvegy et al (2002) JBC, Vol. 277, No: 50, 47980-47980; Lyn Mickley et al (2001) Mammalian Genome 12, 86-88; L. Austin Doyle (1998) PNAS Vol. 95, 15665-15670.

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