Sodium channel protein type 5 subunit alpha; HH1; Sodium channel protein cardiac muscle subunit alpha; Sodium channel protein type V subunit alpha; Voltage-gated sodium channel subunit alpha Nav15; SCN5A

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit Ig

Rabbit

This SCN5A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 42-70 amino acids from the N-terminal region of human SCN5A.

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Vial Concentration: 0.5 (lot specific)

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Small volumes of anti-SCN5A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

The protein encoded by this gene is an integral membrane
protein and tetrodotoxin-resistant voltage-gated sodium channel
subunit. This protein is found primarily in cardiac muscle and is
responsible for the initial upstroke of the action potential in an
electrocardiogram. Defects in this gene are a cause of long QT
syndrome type 3 (LQT3), an autosomal dominant cardiac disease.
Alternative splicing results in several transcript variants
encoding different isoforms.

Cardiovascular; Neuroscience

Western Blot (WB), ELISA (EIA)

WB~~1:1000

SCN5A Antibody (N-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the SCN5A antibody detected the SCN5A protein (arrow).

226940

sodium channel, voltage gated, type V alpha subunit

sodium channel protein type 5 subunit alpha

Sodium channel protein type 5 subunit alpha

SCN5A_HUMAN

The protein encoded by this gene is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. This protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Defects in this gene are a cause of long QT syndrome type 3 (LQT3), an autosomal dominant cardiac disease. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

SCN5A: an integral membrane protein and a voltage-gated sodium channel subunit. Mediates the voltage-dependent sodium ion permeability of excitable membranes. This protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant Na(+) channel isoform. Intracellular calcium levels regulate channel inactivation. Interacts with the PDZ domain of the syntrophin SNTA1, SNTB1 and SNTB2. Interacts with NEDD4, NEDD4L, WWP2 and GPD1L. Defects in this protein are a cause of long QT syndrome type 3 (LQT3). Belongs to the sodium channel (TC 1.A.1.10) family, Nav1.5/SCN5A subfamily. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Channel, sodium; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 3p21

Cellular Component: voltage-gated sodium channel complex; cell surface; endoplasmic reticulum; T-tubule; plasma membrane; integral to membrane; caveola; sarcolemma; lateral plasma membrane

Molecular Function: calmodulin binding; protein binding; enzyme binding; fibroblast growth factor binding; ubiquitin protein ligase binding; voltage-gated sodium channel activity; ankyrin binding; nitric-oxide synthase binding; protein kinase binding

Biological Process: membrane depolarization; axon guidance; telencephalon development; regulation of heart rate; sodium ion transport; generation of action potential; cerebellum development; response to denervation involved in regulation of muscle adaptation; positive regulation of action potential; positive regulation of epithelial cell proliferation; cardiac muscle contraction; odontogenesis of dentine-containing teeth

Disease: Brugada Syndrome 1; Sudden Infant Death Syndrome; Ventricular Fibrillation During Myocardial Infarction, Susceptibility To; Sick Sinus Syndrome 1, Autosomal Recessive; Progressive Familial Heart Block, Type Ia; Long Qt Syndrome 3; Cardiomyopathy, Dilated, 1e; Atrial Fibrillation, Familial, 10

Liu, M., et al. Circ. Res. 107(8):967-974(2010)
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
van Stuijvenberg, L., et al. DNA Cell Biol. 29(10):577-587(2010)
House, C.D., et al. Cancer Res. 70(17):6957-6967(2010)
Garcia-Castro, M., et al. Rev Esp Cardiol 63(7):856-859(2010)

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