Full Product Name
Anti-SCO2 Antibody
Product Synonym Names
Protein SCO2 homolog, mitochondrial
Product Gene Name
anti-SCO2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for O43819
Species Reactivity
Human, Mouse, Rat
Specificity
Recognizes endogenous levels of SCO2 protein.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Immunogen
Recombinant full length protein of human SCO2
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Other Notes
Small volumes of anti-SCO2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-SCO2 antibody
Rabbit polyclonal antibody to SCO2
Applications Tested/Suitable for anti-SCO2 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-SCO2 antibody
Western Blot: 1/500 - 1/2000, Immunohistochemistry: 1/50 - 1/200
Western Blot (WB) of anti-SCO2 antibody
Western blot analysis of SCO2 expression in HL60 (A), SKOV3 (B), mouse brain (C), rat liver (D) whole cell lysates.
Immunohistochemistry (IHC) of anti-SCO2 antibody
Immunohistochemical analysis of SCO2 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
NCBI/Uniprot data below describe general gene information for SCO2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001162580.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001169109.1
[Other Products]
UniProt Primary Accession #
O43819
[Other Products]
UniProt Secondary Accession #
Q3T1B5; Q9UK87[Other Products]
UniProt Related Accession #
O43819[Other Products]
Molecular Weight
29,810 Da
NCBI Official Full Name
protein SCO2 homolog, mitochondrial
NCBI Official Synonym Full Names
SCO2, cytochrome c oxidase assembly protein
NCBI Official Symbol
SCO2??[Similar Products]
NCBI Official Synonym Symbols
MYP6; SCO1L; CEMCOX1
??[Similar Products]
NCBI Protein Information
protein SCO2 homolog, mitochondrial
UniProt Protein Name
Protein SCO2 homolog, mitochondrial
Protein Family
SCO2-like protein
UniProt Gene Name
SCO2??[Similar Products]
UniProt Entry Name
SCO2_HUMAN
NCBI Summary for SCO2
Cytochrome c oxidase (COX) catalyzes the transfer of electrons from cytochrome c to molecular oxygen, which helps to maintain the proton gradient across the inner mitochondrial membrane that is necessary for aerobic ATP production. Human COX is a multimeric protein complex that requires several assembly factors; this gene encodes one of the COX assembly factors. The encoded protein is a metallochaperone that is involved in the biogenesis of cytochrome c oxidase subunit II. Mutations in this gene are associated with fatal infantile encephalocardiomyopathy and myopia 6. [provided by RefSeq, Oct 2014]
UniProt Comments for SCO2
SCO2: Acts as a copper chaperone, transporting copper to the Cu(A) site on the cytochrome c oxidase subunit II (COX2). Defects in SCO2 are the cause of fatal infantile cardioencephalomyopathy with cytochrome c oxidase deficiency (FIC). This disease is characterized by hypertrophic cardiomyopathy, lactic acidosis, and gliosis. Heart and skeletal muscle show reductions in cytochrome c oxidase (COX) activity, whereas liver and fibroblasts show mild COX deficiencies. Belongs to the SCO1/2 family.
Protein type: Mitochondrial
Chromosomal Location of Human Ortholog: 22q13.33
Cellular Component: mitochondrial matrix; mitochondrion; myofibril; nucleoplasm
Molecular Function: protein binding
Biological Process: eye development
Disease: Cardioencephalomyopathy, Fatal Infantile, Due To Cytochrome C Oxidase Deficiency 1; Myopia 6
Research Articles on SCO2
1. oncoprotein HBXIP enhances glucose metabolism reprogramming through suppressing SCO2 and PDHA1 in breast cancer
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
