Product Name
SCO2, cDNA Clone
Full Product Name
SCO2 cDNA Clone
Product Gene Name
SCO2 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
ATGCTGCTGC TGACTCGGAG CCCCACAGCT TGGCACAGGC TCTCTCAGCT CAAGCCTCGG GTCCTCCCTG GGACCCTGGG AGGCCAGGCC CTGCATCTGA GGTCCTGGCT TTTGTCAAGG CAGGGCCCTG CAGAGACAGG TGGGCAGGGC CAGCCCCAGG GCCCTGGGCT TCGAACCCGG CTGCTGATCA CAGGCCTGTT CGGGGCTGGA CTCGGTGGGG CCTGGCTGGC CCTGAGGGCT GAGAAGGAGA GGCTGCAGCA GCAAAAGCGA ACAGAAGCCC TGCGCCAGGC AGCTGTGGGC CAGGGCGACT TCCACCTGCT GGATCACAGA GGCCGGGCTC GCTGCAAGGC TGACTTCCGG GGCCAGTGGG TGCTGATGTA CTTTGGCTTC ACTCACTGCC CTGACATCTG CCCAGACGAG CTGGAGAAGC TGGTGCAGGT GGTGCGGCAG CTGGAAGCAG AGCCTGGTTT GCCTCCAGTG CAGCCTGTCT TCATCACTGT GGACCCCGAG CGGGACGACG TTGAAGCCAT GGCCCGCTAC GTCCAGGACT TCCACCCAAG ACTGTTGGGT CTGACCGGCT CCACCAAACA GGTTGCCCAG GCTAGTCACA GTTACCGCGT GTACTACAAT GCAGGCCCCA AGGATGAGGA CCAGGACTAC ATCGTGGACC ACTCCATTGC CATCTACCTG CTCAACCCTG ACGGCCTCTT CACGGATTAC TACGGCCGGA GCAGATCGGC TGAGCAGATC TCAGACAGTG TGCGGCGGCA CATGGCGGCT TTCCGCAGTG TCCTGTCTTG A
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of SCO2 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for SCO2. It may not necessarily be applicable to this product.
NCBI Accession #
BC102025
[Other Products]
UniProt Secondary Accession #
Q3T1B5; Q9UK87[Other Products]
UniProt Related Accession #
O43819[Other Products]
Molecular Weight
29,810 Da
NCBI Official Full Name
Homo sapiens SCO cytochrome oxidase deficient homolog 2 (yeast), mRNA
NCBI Official Synonym Full Names
SCO2, cytochrome c oxidase assembly protein
NCBI Official Symbol
SCO2??[Similar Products]
NCBI Official Synonym Symbols
MYP6; SCO1L; CEMCOX1
??[Similar Products]
NCBI Protein Information
protein SCO2 homolog, mitochondrial
UniProt Protein Name
Protein SCO2 homolog, mitochondrial
Protein Family
SCO2-like protein
UniProt Gene Name
SCO2??[Similar Products]
UniProt Entry Name
SCO2_HUMAN
NCBI Summary for SCO2
Cytochrome c oxidase (COX) catalyzes the transfer of electrons from cytochrome c to molecular oxygen, which helps to maintain the proton gradient across the inner mitochondrial membrane that is necessary for aerobic ATP production. Human COX is a multimeric protein complex that requires several assembly factors; this gene encodes one of the COX assembly factors. The encoded protein is a metallochaperone that is involved in the biogenesis of cytochrome c oxidase subunit II. Mutations in this gene are associated with fatal infantile encephalocardiomyopathy and myopia 6. [provided by RefSeq, Oct 2014]
UniProt Comments for SCO2
SCO2: Acts as a copper chaperone, transporting copper to the Cu(A) site on the cytochrome c oxidase subunit II (COX2). Defects in SCO2 are the cause of fatal infantile cardioencephalomyopathy with cytochrome c oxidase deficiency (FIC). This disease is characterized by hypertrophic cardiomyopathy, lactic acidosis, and gliosis. Heart and skeletal muscle show reductions in cytochrome c oxidase (COX) activity, whereas liver and fibroblasts show mild COX deficiencies. Belongs to the SCO1/2 family.
Protein type: Mitochondrial
Chromosomal Location of Human Ortholog: 22q13.33
Cellular Component: mitochondrial matrix; mitochondrion; myofibril; nucleoplasm
Molecular Function: protein binding
Biological Process: eye development
Disease: Cardioencephalomyopathy, Fatal Infantile, Due To Cytochrome C Oxidase Deficiency 1; Myopia 6
Research Articles on SCO2
1. oncoprotein HBXIP enhances glucose metabolism reprogramming through suppressing SCO2 and PDHA1 in breast cancer
Precautions
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Disclaimer
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