Product Name
SCO2 (SCO1), Blocking Peptide
Full Product Name
SCO2 Peptide
Product Synonym Names
SCOD1; Protein SCO2 homolog; mitochondrial; SCO cytochrome oxidase deficient homolog 1 (yeast)
Product Gene Name
SCO1 blocking peptide
[Similar Products]
SCO2 peptide (MBS152797) is used for blocking the activity of SCO2 antibody (MBS150350)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for O43819
Concentration
200 ug/mL (lot specific)
Buffer
PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
Location
19 amino acid peptide from near the carboxy terminus of human SCO2
Preparation and Storage
Store SCO2 peptide at -20 degree C, stable for one year.
Other Notes
Small volumes of SCO1 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for SCO1 blocking peptide
Blocking (BL)
Application Notes for SCO1 blocking peptide
SCO2 peptide is used for blocking the activity of SCO2 antibody.
NCBI/Uniprot data below describe general gene information for SCO1. It may not necessarily be applicable to this product.
NCBI Accession #
O43819.3
[Other Products]
UniProt Primary Accession #
O43819
[Other Products]
UniProt Secondary Accession #
Q3T1B5; Q9UK87[Other Products]
UniProt Related Accession #
O43819[Other Products]
Molecular Weight
29,810 Da
NCBI Official Full Name
Protein SCO2 homolog, mitochondrial
NCBI Official Synonym Full Names
SCO2 cytochrome c oxidase assembly protein
NCBI Official Symbol
SCO2??[Similar Products]
NCBI Official Synonym Symbols
MYP6; SCO1L; CEMCOX1
??[Similar Products]
NCBI Protein Information
protein SCO2 homolog, mitochondrial; SCO cytochrome oxidase deficient homolog 2
UniProt Protein Name
Protein SCO2 homolog, mitochondrial
Protein Family
SCO2-like protein
UniProt Gene Name
SCO2??[Similar Products]
UniProt Entry Name
SCO2_HUMAN
NCBI Summary for SCO1
Cytochrome c oxidase (COX) catalyzes the transfer of electrons from cytochrome c to molecular oxygen, which helps to maintain the proton gradient across the inner mitochondrial membrane that is necessary for aerobic ATP production. Human COX is a multimeric protein complex that requires several assembly factors; this gene encodes one of the COX assembly factors. The encoded protein is a metallochaperone that is involved in the biogenesis of cytochrome c oxidase subunit II. Mutations in this gene are associated with fatal infantile encephalocardiomyopathy and myopia 6. [provided by RefSeq, Oct 2014]
UniProt Comments for SCO1
SCO2: Acts as a copper chaperone, transporting copper to the Cu(A) site on the cytochrome c oxidase subunit II (COX2). Defects in SCO2 are the cause of fatal infantile cardioencephalomyopathy with cytochrome c oxidase deficiency (FIC). This disease is characterized by hypertrophic cardiomyopathy, lactic acidosis, and gliosis. Heart and skeletal muscle show reductions in cytochrome c oxidase (COX) activity, whereas liver and fibroblasts show mild COX deficiencies. Belongs to the SCO1/2 family.
Protein type: Mitochondrial
Chromosomal Location of Human Ortholog: 22q13.33
Cellular Component: nucleoplasm; myofibril; mitochondrion; mitochondrial inner membrane
Molecular Function: copper ion binding
Biological Process: cellular copper ion homeostasis; eye development; in utero embryonic development; respiratory chain complex IV assembly; response to activity; muscle system process; copper ion transport
Disease: Cardioencephalomyopathy, Fatal Infantile, Due To Cytochrome C Oxidase Deficiency 1; Myopia 6
Research Articles on SCO1
1. COX20 cooperates with SCO1 and SCO2 to mature COX2 and promote the assembly of cytochrome c oxidase.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
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