Full Product Name
SCO2 Antibody
Product Synonym Names
Synthesis of cytochrome c oxidase 2, cytochrome oxidase deficient homolog 2
Product Gene Name
anti-SCO2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for O43819
Purity/Purification
Affinity chromatography purified via peptide column
Form/Format
Supplied in PBS containing 0.02% sodium azide.
Immunogen Description
Raised against a 19 amino acid peptide from near the carboxy terminus of human SCO2.
Preparation and Storage
Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Other Notes
Small volumes of anti-SCO2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-SCO2 antibody
Synthesis of cytochrome c oxidase 2 was initially identified in yeast as one of two cytochrome c oxidase (COX) assembly proteins that enable the assembly of cytochrome c holoenzyme, a complex that catalyzes the transfer of reducing equivalents from cytochrome c to molecular oxygen and pumps protons across the inner mitochondrial membrane. Like their yeast homologs, the function of both SCO2 and SCO1 are dependent on copper ion binding. Recent studies suggest that SCO2 expression is regulated by p53, so that a decrease in p53 expression, such as in numerous tumors and cells lines, the drop in SCO2 expression leads to a shift from normal aerobic respiration towards the production of glycolytic ATP. Defects in the SCO2 protein are also associated with fatal infantile cardioencephalomyopathy and COX deficiency.
Product Categories/Family for anti-SCO2 antibody
Total protein Ab
Applications Tested/Suitable for anti-SCO2 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Western Blot (WB) of anti-SCO2 antibody
Western blot analysis of SCO2 in human liver tissue lysate with SCO2 antibody at (A) 0.5, (B) 1 and (C) 2 ug/mL.
Immunohistochemistry (IHC) of anti-SCO2 antibody
Immunohistochemistry of SCO2 in human liver tissue with SCO2 antibody at 2.5 ug/mL.
NCBI/Uniprot data below describe general gene information for SCO2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001162580.1
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NCBI GenBank Nucleotide #
NM_001169109.1
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UniProt Primary Accession #
O43819
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UniProt Secondary Accession #
Q3T1B5; Q9UK87[Other Products]
UniProt Related Accession #
O43819[Other Products]
Molecular Weight
29,810 Da
NCBI Official Full Name
protein SCO2 homolog, mitochondrial
NCBI Official Synonym Full Names
SCO2 cytochrome c oxidase assembly protein
NCBI Official Symbol
SCO2??[Similar Products]
NCBI Official Synonym Symbols
MYP6; SCO1L; CEMCOX1
??[Similar Products]
NCBI Protein Information
protein SCO2 homolog, mitochondrial
UniProt Protein Name
Protein SCO2 homolog, mitochondrial
Protein Family
SCO2-like protein
UniProt Gene Name
SCO2??[Similar Products]
UniProt Entry Name
SCO2_HUMAN
NCBI Summary for SCO2
Cytochrome c oxidase (COX) catalyzes the transfer of electrons from cytochrome c to molecular oxygen, which helps to maintain the proton gradient across the inner mitochondrial membrane that is necessary for aerobic ATP production. Human COX is a multimeric protein complex that requires several assembly factors; this gene encodes one of the COX assembly factors. The encoded protein is a metallochaperone that is involved in the biogenesis of cytochrome c oxidase subunit II. Mutations in this gene are associated with fatal infantile encephalocardiomyopathy and myopia 6. [provided by RefSeq, Oct 2014]
UniProt Comments for SCO2
SCO2: Acts as a copper chaperone, transporting copper to the Cu(A) site on the cytochrome c oxidase subunit II (COX2). Defects in SCO2 are the cause of fatal infantile cardioencephalomyopathy with cytochrome c oxidase deficiency (FIC). This disease is characterized by hypertrophic cardiomyopathy, lactic acidosis, and gliosis. Heart and skeletal muscle show reductions in cytochrome c oxidase (COX) activity, whereas liver and fibroblasts show mild COX deficiencies. Belongs to the SCO1/2 family.
Protein type: Mitochondrial
Chromosomal Location of Human Ortholog: 22q13.33
Cellular Component: nucleoplasm; myofibril; mitochondrion; mitochondrial inner membrane
Molecular Function: copper ion binding
Biological Process: cellular copper ion homeostasis; eye development; in utero embryonic development; respiratory chain complex IV assembly; response to activity; copper ion transport; muscle system process
Disease: Cardioencephalomyopathy, Fatal Infantile, Due To Cytochrome C Oxidase Deficiency 1; Myopia 6
Research Articles on SCO2
1. Letter/Case Report: SCO2 mutations resulting in Leigh disease revealed at autopsy.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
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