Product Name
Neurofilament light polypeptide (NFL), Recombinant Protein
Popular Item
Full Product Name
Recombinant Mus musculus Neurofilament light polypeptide
Product Synonym Names
68 kDa neurofilament protein; Neurofilament triplet L protein
Product Gene Name
NFL recombinant protein
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
Full Length, 2-543aa
Sequence
SSFGYDPYFS TSYKRRYVET PRVHISSVRS GYSTARSAYS SYSAPVSSSL SVRRSYSSSS GSLMPSLENL DLSQVAAISN DLKSIRTQEK AQLQDLNDRF ASFIERVHEL EQQNKVLEAE LLVLRQKHSE PSRFRALYEQ EIRDLRLAAE DATNEKQALQ GEREGLEETL RNLQARYEEE VLSREDAEGR LMEARKGADE AALARAELEK RIDSLMDEIA FLKKVHEEEI AELQAQIQYA QISVEMDVSS KPDLSAALKD IRAQYEKLAA KNMQNAEEWF KSRFTVLTES AAKNTDAVRA AKDEVSESRR LLKAKTLEIE ACRGMNEALE KQLQELEDKQ NADISAMQDT INKLENELRS TKSEMARYLK EYQDLLNVKM ALDIEIAAYR KLLEGEETRL SFTSVGSITS GYSQSSQVFG RSAYSGLQSS SYLMSARSFP AYYTSHVQEE QTEVEETIEA TKAEEAKDEP PSEGEAEEEE KEKEEGEEEE GAEEEEAAKD ESEDTKEEEE GGEGEEEDTK ESEEEEKKEE SAGEEQVAKK KD
3D Structure
ModBase 3D Structure for P08551
Purity/Purification
Greater than 90% as determined by SDS-PAGE.
Form/Format
20mM Tris-HCl based buffer, pH8.0
Target Length
Full length-2-543
Preparation and Storage
Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Other Notes
Small volumes of NFL recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
NFL recombinant protein
Recombinant protein
Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber.
NCBI/Uniprot data below describe general gene information for NFL. It may not necessarily be applicable to this product.
NCBI Accession #
NP_035040.1
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NCBI GenBank Nucleotide #
NM_010910.1
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UniProt Primary Accession #
P08551
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UniProt Secondary Accession #
Q8K0Z0[Other Products]
UniProt Related Accession #
P08551[Other Products]
NCBI Official Full Name
neurofilament light polypeptide
NCBI Official Synonym Full Names
neurofilament, light polypeptide
NCBI Official Symbol
Nefl??[Similar Products]
NCBI Official Synonym Symbols
Nfl; NF-L; NF68; CMT2E; AI847934
??[Similar Products]
NCBI Protein Information
neurofilament light polypeptide
UniProt Protein Name
Neurofilament light polypeptide
UniProt Synonym Protein Names
68 kDa neurofilament protein; Neurofilament triplet L protein
Protein Family
Neurofilament light polypeptide
UniProt Gene Name
Nefl??[Similar Products]
UniProt Synonym Gene Names
Nf68; Nfl; NF-L??[Similar Products]
UniProt Comments for NFL
NFL: one of the three (L, M, and H) intermediate filament proteins that form neurofilaments. Neurofilaments are involved in the maintenance of neuronal caliber. NF-L is the most abundant of the three neurofilament proteins. Defects cause Charcot-Marie-Tooth disease type 1F (CMT1F).
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 14|14 D1
Cellular Component: axon; cytoplasm; growth cone; intermediate filament; myelin sheath; neurofilament; neuron projection; TSC1-TSC2 complex
Molecular Function: identical protein binding; phospholipase binding; protein binding; protein binding, bridging; protein C-terminus binding; protein domain specific binding; protein heterodimerization activity; structural constituent of cytoskeleton
Biological Process: anterograde axon cargo transport; axon regeneration in the peripheral nervous system; axon transport of mitochondrion; intermediate filament bundle assembly; intermediate filament organization; intermediate filament polymerization and/or depolymerization; locomotion; microtubule cytoskeleton organization and biogenesis; negative regulation of neuron apoptosis; neurite morphogenesis; neurofilament bundle assembly; neurofilament cytoskeleton organization and biogenesis; neuromuscular process controlling balance; positive regulation of axonogenesis; protein polymerization; regulation of axon diameter; retrograde axon cargo transport
Research Articles on NFL
1. It may have a role in protecting neurites from dystrophy and in regulating cellular pathways related to the generation of Ab plaques.
Precautions
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Disclaimer
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