Full Product Name
Goat anti-KCNE3 Antibody
Product Synonym Names
KCNE3; potassium voltage-gated channel, Isk-related family, member 3; DKFZp781H21101; HOKPP; MGC102685; MGC129924; MiRP2; cardiac voltage-gated potassium channel accessory subunit; minK-related peptide 2; minimum potassium ion channel-related peptide 2; p; KCNE3 antibody; potassium voltage-gated channel; Isk-related family; member 3 antibody; DKFZp781H21101 antibody; HOKPP antibody; MGC102685 antibody; MGC129924 antibody; MiRP2 antibody; ardiac voltage-gated potassium channel accessory subunit antibody; minK-related peptide 2 antibody; minimum potassium ion channel-related peptide 2 antibody; potassium voltage-gated channel subfamily E member 3 antibody; voltage-gated K+ channel subunit MIRP2 antibody
Product Gene Name
anti-KCNE3 antibody
[Similar Products]
Antibody/Peptide Pairs
KCNE3 peptide (MBS427256) is used for blocking the activity of KCNE3 antibody (MBS422274)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
PDNQTEERRA SLP
Species Reactivity
Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow, Pig
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Concentration
100ug specific antibody in 200ul (lot specific)
Immunogen
Peptide with sequence C-PDNQTEERRASLP, from the Internal region of the protein sequence according to NP_005463.1.
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-KCNE3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-KCNE3 antibody
Peptide ELISA (EIA)
Application Notes for anti-KCNE3 antibody
Peptide ELISA: Antibody detection limit dilution 1: 1000.
Western Blot: Preliminary experiments in Human, Mouse and Rat Skeletal Muscle lysates gave no specific signal but low background (at antibody concentration up to 1ug/ml).
NCBI/Uniprot data below describe general gene information for KCNE3. It may not necessarily be applicable to this product.
NCBI Accession #
NP_005463.1
[Other Products]
NCBI GenBank Nucleotide #
NM_005472.4
[Other Products]
UniProt Related Accession #
Q9Y6H6[Other Products]
Molecular Weight
11,710 Da
NCBI Official Full Name
potassium voltage-gated channel subfamily E member 3
NCBI Official Synonym Full Names
potassium voltage-gated channel subfamily E regulatory subunit 3
NCBI Official Symbol
KCNE3??[Similar Products]
NCBI Official Synonym Symbols
HYPP; HOKPP; MiRP2
??[Similar Products]
NCBI Protein Information
potassium voltage-gated channel subfamily E member 3
UniProt Protein Name
Potassium voltage-gated channel subfamily E member 3
UniProt Synonym Protein Names
MinK-related peptide 2; Minimum potassium ion channel-related peptide 2; Potassium channel subunit beta MiRP2
Protein Family
Potassium voltage-gated channel subfamily
UniProt Gene Name
KCNE3??[Similar Products]
UniProt Entry Name
KCNE3_HUMAN
NCBI Summary for KCNE3
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a type I membrane protein, and a beta subunit that assembles with a potassium channel alpha-subunit to modulate the gating kinetics and enhance stability of the multimeric complex. This gene is prominently expressed in the kidney. A missense mutation in this gene is associated with hypokalemic periodic paralysis. [provided by RefSeq, Jul 2008]
UniProt Comments for KCNE3
KCNE3: Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Belongs to the potassium channel KCNE family.
Protein type: Channel, potassium
Chromosomal Location of Human Ortholog: 11q13.4
Cellular Component: cytoplasm; dendrite; lipid raft; perikaryon; plasma membrane; vesicle; voltage-gated potassium channel complex
Molecular Function: potassium channel regulator activity; protein binding; voltage-gated potassium channel activity
Disease: Brugada Syndrome 6
Research Articles on KCNE3
1. KCNE1 and KCNE3: The yin and yang of voltage-gated K(+) channel regulation
Precautions
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Disclaimer
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