Full Product Name
Rabbit Polyclonal to Human KCNE3
Product Synonym Names
Anti-KCNE3 Antibody (Internal) IHC-plus; KCNE3; MinK-related peptide 2; HOKPP; HYPP; MiRP2; Human KCNE3
Product Gene Name
anti-KCNE3 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9Y6H6
Species Reactivity
Bat, Gibbon, Bovine, Chicken, Dog, Gorilla, Hamster, Horse, Human, Mouse, Pig, Rabbit, Rat
Predicted Reactivity: Monkey, Xenopus (at least 90% immunogen sequence identity)
Specificity
Human KCNE3. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Purity/Purification
Immunoaffinity Purified
Form/Format
PBS, 0.1% sodium azide.
Concentration
1 mg/ml (lot specific)
Immunogen Description
Synthetic 14 amino acid peptide from internal region of human KCNE3. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Mouse, Rat, Hamster, Elephant, Panda, Bovine, Dog, Bat, Horse, Rabbit, Pig, Opossum, Chicken.
Immunogen Type
Synthetic peptide
Immunogen
KCNE3 antibody was raised against synthetic 14 amino acid peptide from internal region of human KCNE3. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Mouse, Rat, Hamster, Elephant, Panda, Bovine, Dog, Bat, Horse, Rabbit, Pig, Opossum, Chicken, Platypus (100%); Marmoset, Xenopus (93%).
Antigen Modification
Internal
Preparation and Storage
Long term: -70 degree C; Short term: +4 degree C
Other Notes
Small volumes of anti-KCNE3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-KCNE3 antibody
Subfamily:-Potassium-channel---KCNE">Family: Ion Channel
Subfamily: Potassium channel - KCNE
Applications Tested/Suitable for anti-KCNE3 antibody
Immunohistochemistry (IHC - Paraffin)
Application Notes for anti-KCNE3 antibody
IHC-P (10 - 20 ug/ml)
Immunohistochemistry (IHC) of anti-KCNE3 antibody
Anti-KCNE3 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
NCBI/Uniprot data below describe general gene information for KCNE3. It may not necessarily be applicable to this product.
NCBI Accession #
NP_005463.1
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NCBI GenBank Nucleotide #
NM_005472.4
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UniProt Primary Accession #
Q9Y6H6
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UniProt Related Accession #
Q9Y6H6[Other Products]
Molecular Weight
11,710 Da
NCBI Official Full Name
potassium voltage-gated channel subfamily E member 3
NCBI Official Synonym Full Names
potassium voltage-gated channel, Isk-related family, member 3
NCBI Official Symbol
KCNE3??[Similar Products]
NCBI Official Synonym Symbols
HYPP; HOKPP; MiRP2
??[Similar Products]
NCBI Protein Information
potassium voltage-gated channel subfamily E member 3; minK-related peptide 2; potassium channel subunit beta MiRP2; voltage-gated K+ channel subunit MIRP2; minimum potassium ion channel-related peptide 2; cardiac voltage-gated potassium channel accessory subunit
UniProt Protein Name
Potassium voltage-gated channel subfamily E member 3
UniProt Synonym Protein Names
MinK-related peptide 2; Minimum potassium ion channel-related peptide 2; Potassium channel subunit beta MiRP2
Protein Family
Potassium voltage-gated channel subfamily
UniProt Gene Name
KCNE3??[Similar Products]
UniProt Entry Name
KCNE3_HUMAN
NCBI Summary for KCNE3
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a type I membrane protein, and a beta subunit that assembles with a potassium channel alpha-subunit to modulate the gating kinetics and enhance stability of the multimeric complex. This gene is prominently expressed in the kidney. A missense mutation in this gene is associated with hypokalemic periodic paralysis. [provided by RefSeq, Jul 2008]
UniProt Comments for KCNE3
KCNE3: Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Belongs to the potassium channel KCNE family.
Protein type: Channel, potassium
Chromosomal Location of Human Ortholog: 11q13.4
Cellular Component: voltage-gated potassium channel complex
Molecular Function: voltage-gated potassium channel activity; potassium channel regulator activity
Disease: Brugada Syndrome 6
Research Articles on KCNE3
1. A KCNE3 T4A mutation was identified in a Japanese patient presenting Brugada-pattern ECG and neurally mediated syncope.
Precautions
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Disclaimer
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