Product Name
TSC1, cDNA Clone
Popular Item
Full Product Name
TSC1 cDNA Clone
Product Gene Name
TSC1 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atggcccaac aagcaaatgt cggggagctt cttgccatgc tggactcccc catgctgggt gtgcgggacg acgtgacagc tgtctttaaa gagaacctca attctgaccg tggccctatg cttgtaaaca ccttggtgga ttattacctg gaaaccagct ctcagccggc attgcacatc ctgaccacct tgcaagagcc acatgacaag cacctcttgg acaggattaa cgaatatgtg ggcaaagccg ccactcgttt atccatcctc tcgttactgg gtcatgtcat aagactgcag ccatcttgga agcataagct ctctcaagca cctcttttgc cttctttact aaaatgtctc aagatggaca ctgacgtcgt tgtcctcaca acaggcgtct tggtgttgat aaccatgcta ccaatgattc cacagtctgg gaaacagcat cttcttgatt tctttgacat ttttggccgt ctgtcatcat ggtgcctgaa gaaaccaggc cacgtggcgg aagtctatct cgtccatctc catgccagtg tgtacgcact ctttcatcgc ctttatggaa tgtacccttg caacttcgtc tcctttttgc gttctcatta cagtatgaaa gaaaacctgg agacttttga agaagtggtc aagccaatga tggagcatgt gcgaattcat ccggaattag tgactggatc caaggaccat gaactggacc ctcgaaggtg gaagagatta gaaactcatg atgttgtgat cgagtgtgcc aaaatctctc tggatcccac agaagcctca tatgaagatg gctattctgt gtctcaccaa atctcagccc gctttcctca tcgttcagcc gatgtcacca ccagccctta tgctgacaca cagaatagct atgggtgtgc tacttctacc ccttactcca cgtctcggct gatgttgtta aatatgccag ggcagctacc tcagactctg agttccccat cgacacggct gataactgaa ccaccacaag tatggtgtca actagtgtgc ctgctctctc ctctgctttc tggtgaagct gaccctttgg gtcagattta g
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of TSC1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for TSC1. It may not necessarily be applicable to this product.
NCBI Accession #
BC047772
[Other Products]
UniProt Secondary Accession #
Q5VVN5; B7Z897[Other Products]
UniProt Related Accession #
Q92574[Other Products]
Molecular Weight
124,015 Da
NCBI Official Full Name
Homo sapiens tuberous sclerosis 1, mRNA
NCBI Official Synonym Full Names
tuberous sclerosis 1
NCBI Official Symbol
TSC1??[Similar Products]
NCBI Official Synonym Symbols
LAM; TSC
??[Similar Products]
NCBI Protein Information
hamartin
UniProt Protein Name
Hamartin
UniProt Synonym Protein Names
Tuberous sclerosis 1 protein
Protein Family
Tuberous sclerosis 1 protein
UniProt Gene Name
TSC1??[Similar Products]
UniProt Synonym Gene Names
KIAA0243; TSC??[Similar Products]
UniProt Entry Name
TSC1_HUMAN
NCBI Summary for TSC1
This gene encodes a growth inhibitory protein thought to play a role in the stabilization of tuberin. Mutations in this gene have been associated with tuberous sclerosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009]
UniProt Comments for TSC1
TSC1: tuberous sclerosis protein 1 (TSC1). May have tumor suppressor activity. Together with tuberin (TSC2), inhibits mammalian target of rapamycin (mTOR)-mediated signaling to eukaryotic initiation factor 4E-binding protein 1 (4E-BP1) and ribosomal protein S6 kinase. Regulated by the phosphatidylinositol 3-kinase/Akt pathway and phosphorylation of tuberin. Phosphorylated by cyclin-dependent kinase 1/cyclin B during the cell cycle.
Protein type: Motility/polarity/chemotaxis; Tumor suppressor
Chromosomal Location of Human Ortholog: 9q34
Cellular Component: actin filament; cell cortex; cytoplasm; cytosol; lamellipodium; membrane; nucleus; perinuclear region of cytoplasm; plasma membrane; protein complex; TSC1-TSC2 complex
Molecular Function: chaperone binding; GTPase regulator activity; protein binding; protein N-terminus binding
Biological Process: ***** locomotory behavior; cell cycle arrest; cell-matrix adhesion; negative regulation of cell proliferation; negative regulation of insulin receptor signaling pathway; negative regulation of macroautophagy; negative regulation of TOR signaling pathway; negative regulation of translation; positive regulation of focal adhesion formation; protein stabilization; regulation of cell cycle; regulation of cell-matrix adhesion; regulation of phosphoprotein phosphatase activity; regulation of stress fiber formation; regulation of translation; response to insulin stimulus; rRNA export from nucleus
Disease: Focal Cortical Dysplasia Of Taylor; Lymphangioleiomyomatosis; Tuberous Sclerosis 1
Research Articles on TSC1
1. AKT3 has a role in prostate cancer proliferation through regulation of Akt, B-Raf, and TSC1/TSC2
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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