Product Name
TSC1 (T1043), Blocking Peptide
Full Product Name
Phospho-mouse TSC1(T1043) Blocking Peptide
Product Synonym Names
Hamartin; Tuberous sclerosis 1 protein homolog; Tsc1; Kiaa0243
Product Gene Name
Tsc1 blocking peptide
[Similar Products]
Product Synonym Gene Name
Kiaa0243[Similar Products]
TSC1 (T1043) peptide (MBS9230788) is used for blocking the activity of TSC1 (T1043) antibody (MBS9211296)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9EP53
Specificity
The synthetic peptide sequence is selected from aa 1039-1051 of MOUSE Tsc1
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Cellular Location
Cytoplasm. Membrane; Peripheral membrane protein. Note: At steady state found in association with membranes.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Other Notes
Small volumes of Tsc1 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
Tsc1 blocking peptide
In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (By similarity). Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling (By similarity).
NCBI/Uniprot data below describe general gene information for Tsc1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_075025.2
[Other Products]
NCBI GenBank Nucleotide #
NM_022887.4
[Other Products]
UniProt Primary Accession #
Q9EP53
[Other Products]
UniProt Secondary Accession #
Q3UHF2; Q7TS92; Q80U55; Q924U7; A2AHW1[Other Products]
UniProt Related Accession #
Q9EP53[Other Products]
Molecular Weight
127,377 Da
NCBI Official Full Name
hamartin isoform 2
NCBI Official Synonym Full Names
tuberous sclerosis 1
NCBI Official Symbol
Tsc1??[Similar Products]
NCBI Protein Information
hamartin
UniProt Protein Name
Hamartin
UniProt Synonym Protein Names
Tuberous sclerosis 1 protein homolog
Protein Family
Tuberous sclerosis 1 protein
UniProt Gene Name
Tsc1??[Similar Products]
UniProt Synonym Gene Names
Kiaa0243??[Similar Products]
UniProt Entry Name
TSC1_MOUSE
UniProt Comments for Tsc1
TSC1: tuberous sclerosis protein 1 (TSC1). May have tumor suppressor activity. Together with tuberin (TSC2), inhibits mammalian target of rapamycin (mTOR)-mediated signaling to eukaryotic initiation factor 4E-binding protein 1 (4E-BP1) and ribosomal protein S6 kinase. Regulated by the phosphatidylinositol 3-kinase/Akt pathway and phosphorylation of tuberin. Phosphorylated by cyclin-dependent kinase 1/cyclin B during the cell cycle.
Protein type: Motility/polarity/chemotaxis; Tumor suppressor
Cellular Component: actin filament; cell cortex; cytoplasm; cytoskeleton; cytosol; growth cone; intracellular membrane-bound organelle; lamellipodium; membrane; nucleus; perinuclear region of cytoplasm; plasma membrane; protein complex; TSC1-TSC2 complex
Molecular Function: chaperone binding; GTPase activating protein binding; GTPase regulator activity; protein binding; protein N-terminus binding
Biological Process: adaptive immune response; ***** locomotory behavior; cardiac muscle cell differentiation; cell projection organization and biogenesis; cell-matrix adhesion; cerebral cortex development; embryonic development; glucose import; hippocampus development; kidney development; memory T cell differentiation; myelination; negative regulation of cell proliferation; negative regulation of cell size; negative regulation of insulin receptor signaling pathway; negative regulation of macroautophagy; negative regulation of TOR signaling pathway; negative regulation of translation; nervous system development; neural tube closure; positive regulation of focal adhesion formation; potassium ion transport; protein heterooligomerization; protein stabilization; regulation of actin cytoskeleton organization and biogenesis; regulation of cell cycle; regulation of cell-matrix adhesion; regulation of focal adhesion formation; regulation of GTPase activity; regulation of phosphoprotein phosphatase activity; regulation of protein kinase activity; regulation of stress fiber formation; regulation of translation; response to insulin stimulus; rRNA export from nucleus; synapse organization and biogenesis
Research Articles on Tsc1
1. Tsc1 plays a critical role in regulating macrophage survival, function and polarization via inhibition of mTORC1 activity.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
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