Full Product Name
NEK1 Antibody
Product Synonym Names
SRPS2; SRPS2A; NY-REN-55
Product Gene Name
anti-NEK1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q96PY6
Species Reactivity
Human, Mouse
Specificity
The antibody detects endogenous levels of total NEK1 protein.
Purity/Purification
Antigen affinity purification.
Form/Format
Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Concentration
1 mg/ml (lot specific)
Immunogen Description
Synthetic peptide corresponding to a region derived from internal residues of human NIMA-related kinase 1
Preparation and Storage
Store at -20 degree C
Other Notes
Small volumes of anti-NEK1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-NEK1 antibody
The protein encoded by this gene is a serine/threonine kinase involved in cell cycle regulation. The encoded protein is found in a centrosomal complex with FEZ1, a neuronal protein that plays a role in axonal development. Defects in this gene are a cause of polycystic kidney disease (PKD). Several transcript variants encoding different isoforms have been found for this gene.
Product Categories/Family for anti-NEK1 antibody
Total protein Ab
Applications Tested/Suitable for anti-NEK1 antibody
Immunohistochemistry (IHC)
Application Notes for anti-NEK1 antibody
Immunohistochemistry: 1:25-1:100
Immunohistochemistry (IHC) of anti-NEK1 antibody
Immunohistochemical analysis of paraffin-embedded Human lymphoma tissue using at dilution 1/25.
Immunohistochemistry (IHC) of anti-NEK1 antibody
Immunohistochemical analysis of paraffin-embedded Human lung cancer tissue using at dilution 1/25.
NCBI/Uniprot data below describe general gene information for NEK1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001186326.1
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NCBI GenBank Nucleotide #
NM_001199397.1
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UniProt Primary Accession #
Q96PY6
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UniProt Secondary Accession #
Q05DG5; Q14CB7; Q5H9T1; Q6PIB8; Q96SS2; Q9H6P7; Q9Y594; G5E9Z3[Other Products]
UniProt Related Accession #
Q96PY6[Other Products]
Molecular Weight
141,053 Da
NCBI Official Full Name
serine/threonine-protein kinase Nek1 isoform 1
NCBI Official Synonym Full Names
NIMA-related kinase 1
NCBI Official Symbol
NEK1??[Similar Products]
NCBI Official Synonym Symbols
SRPS2; SRTD6; SRPS2A; NY-REN-55
??[Similar Products]
NCBI Protein Information
serine/threonine-protein kinase Nek1
UniProt Protein Name
Serine/threonine-protein kinase Nek1
UniProt Synonym Protein Names
Never in mitosis A-related kinase 1; NimA-related protein kinase 1; Renal carcinoma antigen NY-REN-55
Protein Family
Serine/threonine-protein kinase
UniProt Gene Name
NEK1??[Similar Products]
UniProt Synonym Gene Names
KIAA1901; NimA-related protein kinase 1??[Similar Products]
UniProt Entry Name
NEK1_HUMAN
NCBI Summary for NEK1
The protein encoded by this gene is a serine/threonine kinase involved in cell cycle regulation. The encoded protein is found in a centrosomal complex with FEZ1, a neuronal protein that plays a role in axonal development. Defects in this gene are a cause of polycystic kidney disease (PKD). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2010]
UniProt Comments for NEK1
NEK1: a protein kinase related to the NIMA (never in mitosis, gene A) serine/threonine kinase of Aspergillus nidulans. Expressed at high levels during gametogenesis and neurons of the peripheral ganglia. Implicated in the control of meiosis. Mouse mutants lead to facial malformation, male sterility and polycystic kidney disease. Two alternatively spliced human isoforms have been reported.
Protein type: Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Other group; NEK family
Chromosomal Location of Human Ortholog: 4q33
Cellular Component: centrosome; pericentriolar material; cytoplasm; nucleus
Molecular Function: MAP kinase kinase activity; protein serine/threonine kinase activity; protein binding; protein-tyrosine kinase activity; metal ion binding; ATP binding; protein kinase activity
Biological Process: mitosis; peptidyl-tyrosine phosphorylation; activation of MAPK activity; cell division; MAPKKK cascade; cilium biogenesis; response to ionizing radiation; response to DNA damage stimulus
Disease: Short-rib Thoracic Dysplasia 6 With Or Without Polydactyly
Research Articles on NEK1
1. Nek1 may facilitate S-phase progression by interacting with Ku80 and regulating chromatin loading of replication factors.
Precautions
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Disclaimer
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