Human Serine/threonine-protein kinase Nek1 (NEK1) ELISA kit; DKFZp686D06121; DKFZp686K12169; KIAA1901; MGC138800; NY-REN-55; NIMA-related kinase 1; protein-serine/threonine kinase; serine/threonine-protein kinase Nek1; NIMA (never in mitosis gene a) -related kinase 1

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of NEK1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9340866 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the NIMA (never in mitosis gene a) -related kinase 1 (NEK1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing NEK1. The ELISA analytical biochemical technique of the MBS9340866 kit is based on NEK1 antibody-NEK1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect NEK1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, NEK1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

142,828 Da

NIMA-related kinase 1

serine/threonine-protein kinase Nek1; nimA-related protein kinase 1; protein-serine/threonine kinase; renal carcinoma antigen NY-REN-55; never in mitosis A-related kinase 1; NIMA (never in mitosis gene a)-related kinase 1

Serine/threonine-protein kinase Nek1

KIAA1901; NimA-related protein kinase 1??[Similar Products]

NEK1_HUMAN

The protein encoded by this gene is a serine/threonine kinase involved in cell cycle regulation. The encoded protein is found in a centrosomal complex with FEZ1, a neuronal protein that plays a role in axonal development. Defects in this gene are a cause of polycystic kidney disease (PKD). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2010]

NEK1: a protein kinase related to the NIMA (never in mitosis, gene A) serine/threonine kinase of Aspergillus nidulans. Expressed at high levels during gametogenesis and neurons of the peripheral ganglia. Implicated in the control of meiosis. Mouse mutants lead to facial malformation, male sterility and polycystic kidney disease. Two alternatively spliced human isoforms have been reported.

Protein type: Protein kinase, Other; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Other group; NEK family

Chromosomal Location of Human Ortholog: 4q33

Cellular Component: centrosome; pericentriolar material; cytoplasm; nucleus

Molecular Function: MAP kinase kinase activity; protein serine/threonine kinase activity; protein binding; metal ion binding; protein-tyrosine kinase activity; ATP binding; protein kinase activity

Biological Process: mitosis; peptidyl-tyrosine phosphorylation; cell division; activation of MAPK activity; MAPKKK cascade; cilium biogenesis; response to ionizing radiation; response to DNA damage stimulus

Disease: Short-rib Thoracic Dysplasia 6 With Or Without Polydactyly

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