Product Name
Serine/threonine-protein kinase Nek1 (NEK1), Recombinant Protein
Full Product Name
Recombinant Human Serine/threonine-protein kinase Nek1 (NEK1) , partial
Product Gene Name
NEK1 recombinant protein
[Similar Products]
Product Synonym Gene Name
NEK1[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q96PY6
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of NEK1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for NEK1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001186326.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001199397.1
[Other Products]
UniProt Primary Accession #
Q96PY6
[Other Products]
UniProt Secondary Accession #
Q05DG5; Q14CB7; Q5H9T1; Q6PIB8; Q96SS2; Q9H6P7; Q9Y594; G5E9Z3[Other Products]
UniProt Related Accession #
Q96PY6[Other Products]
Molecular Weight
141,053 Da
NCBI Official Full Name
serine/threonine-protein kinase Nek1 isoform 1
NCBI Official Synonym Full Names
NIMA related kinase 1
NCBI Official Symbol
NEK1??[Similar Products]
NCBI Official Synonym Symbols
ALS24; SRPS2; SRTD6; SRPS2A; NY-REN-55
??[Similar Products]
NCBI Protein Information
serine/threonine-protein kinase Nek1
UniProt Protein Name
Serine/threonine-protein kinase Nek1
UniProt Synonym Protein Names
Never in mitosis A-related kinase 1; NimA-related protein kinase 1; Renal carcinoma antigen NY-REN-55
Protein Family
Serine/threonine-protein kinase
UniProt Gene Name
NEK1??[Similar Products]
UniProt Synonym Gene Names
KIAA1901; NimA-related protein kinase 1??[Similar Products]
NCBI Summary for NEK1
The protein encoded by this gene is a serine/threonine kinase involved in cell cycle regulation. The encoded protein is found in a centrosomal complex with FEZ1, a neuronal protein that plays a role in axonal development. Defects in this gene are a cause of polycystic kidney disease (PKD). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2010]
UniProt Comments for NEK1
Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity (). Involved in DNA damage checkpoint control and for proper DNA damage repair. In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death (PubMed:20230784). May be implicated in the control of meiosis (). Involved in cilium assembly (PubMed:21211617).
Research Articles on NEK1
1. This study shown that the NEK1 is a novel in patient with familial amyotrophic lateral sclerosis.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
