Full Product Name
BCHE Antibody
Product Synonym Names
E1; CHE1; CHE2
Product Gene Name
anti-BCHE antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P06276
Specificity
The antibody detects endogenous levels of total BCHE protein.
Purity/Purification
Antigen affinity purification
Form/Format
In pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
Concentration
1.4mg/ml (lot specific)
Immunogen
Synthetic protein corresponding to residues near the C terminal of human BCHE
Preparation and Storage
Store at -20 degree C.
Other Notes
Small volumes of anti-BCHE antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-BCHE antibody
Mutant alleles at the BCHE locus are responsible for suxamethonium sensitivity. Homozygous persons sustain prolonged apnea after administration of the muscle relaxant suxamethonium in connection with surgical anesthesia. The activity of pseudocholinesterase in the serum is low and its substrate behavior is atypical. In the absence of the relaxant, the homozygote is at no known disadvantage.
Product Categories/Family for anti-BCHE antibody
Total protein Ab
Applications Tested/Suitable for anti-BCHE antibody
Immunohistochemistry (IHC)
Application Notes for anti-BCHE antibody
IHC: 1: 50-300
Immunohistochemistry (IHC) of anti-BCHE antibody
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using 46340(BCHE Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200)
NCBI/Uniprot data below describe general gene information for BCHE. It may not necessarily be applicable to this product.
NCBI Accession #
BC008396
[Other Products]
UniProt Primary Accession #
P06276
[Other Products]
UniProt Secondary Accession #
A8K7P8[Other Products]
UniProt Related Accession #
P06276[Other Products]
Molecular Weight
68,418 Da
NCBI Official Full Name
Homo sapiens butyrylcholinesterase, mRNA
NCBI Official Synonym Full Names
butyrylcholinesterase
NCBI Official Symbol
BCHE??[Similar Products]
NCBI Official Synonym Symbols
E1; CHE1; CHE2
??[Similar Products]
NCBI Protein Information
cholinesterase
UniProt Protein Name
Cholinesterase
UniProt Synonym Protein Names
Acylcholine acylhydrolase; Butyrylcholine esterase; Choline esterase II; Pseudocholinesterase
Protein Family
Cholinesterase
UniProt Gene Name
BCHE??[Similar Products]
UniProt Synonym Gene Names
CHE1??[Similar Products]
NCBI Summary for BCHE
This gene encodes a cholinesterase enzyme and member of the type-B carboxylesterase/lipase family of proteins. The encoded enzyme exhibits broad substrate specificity and is involved in the detoxification of poisons including organophosphate nerve agents and pesticides, and the metabolism of drugs including cocaine, heroin and aspirin. Humans homozygous for certain mutations in this gene exhibit prolonged apnea after administration of the muscle relaxant succinylcholine. [provided by RefSeq, Jul 2016]
UniProt Comments for BCHE
Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters.
Research Articles on BCHE
1. BCHE-K* positive subjects (and APOE-epsilon4) display an earlier age of onset of Alzheimer's Disease and an accelerated cognitive decline.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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