Product Name
BSND, cDNA Clone
Full Product Name
BSND cDNA Clone
Product Gene Name
BSND cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atggctgacg agaagacctt ccggatcggc ttcattgtgc tggggctttt cctgctggcc ctcggtacgt tcctcatgag ccatgatcgg ccccaggtct acggcacctt ctatgccatg ggcagcgtca tggtgatcgg gggcatcatc tggagcatgt gccagtgcta ccccaagatc accttcgtcc ctgctgactc tgactttcaa ggcatcctct ccccaaaggc catgggcctg ctggagaatg ggcttgctgc cgagatgaag agccccagtc cccagccgcc ctatgtaagg ctgtgggagg aagccgccta tgaccagagc ctgcctgact tcagccacat ccagatgaaa gtcatgagct acagtgagga ccaccgctcc ttgctggccc tgagatgggg cagccgaagc tgggaaccag tgatggagga gaaggtggcc tggcgacgtt caggcctgga tggaggctgc cgtggtcatc cacaagggct cagacgagag tga
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of BSND cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for BSND. It may not necessarily be applicable to this product.
NCBI Accession #
BC069510
[Other Products]
UniProt Secondary Accession #
Q6NT28[Other Products]
UniProt Related Accession #
Q8WZ55[Other Products]
Molecular Weight
35,197 Da
NCBI Official Full Name
Homo sapiens cDNA clone IMAGE:7262367, containing frame-shift errors
NCBI Official Synonym Full Names
barttin CLCNK type accessory beta subunit
NCBI Official Symbol
BSND??[Similar Products]
NCBI Official Synonym Symbols
BART; DFNB73
??[Similar Products]
NCBI Protein Information
barttin
UniProt Protein Name
Barttin
UniProt Gene Name
BSND??[Similar Products]
UniProt Synonym Gene Names
BART??[Similar Products]
UniProt Entry Name
BSND_HUMAN
NCBI Summary for BSND
This gene encodes an essential beta subunit for CLC chloride channels. These heteromeric channels localize to basolateral membranes of renal tubules and of potassium-secreting epithelia of the inner ear. Mutations in this gene have been associated with Bartter syndrome with sensorineural deafness. [provided by RefSeq, Jul 2008]
UniProt Comments for BSND
BSND: Functions as a beta-subunit for CLCNKA and CLCNKB chloride channels. In the kidney CLCNK/BSND heteromers mediate chloride reabsorption by facilitating its basolateral efflux. In the stria, CLCNK/BSND channels drive potassium secretion by recycling chloride for the basolateral SLC12A2 cotransporter. Defects in BSND are the cause of Bartter syndrome type 4A (BS4A); also known as infantile Bartter syndrome with sensorineural deafness. BS refers to a group of autosomal recessive disorders characterized by impaired salt reabsorption in the thick ascending loop of Henle with pronounced salt wasting, hypokalemic metabolic alkalosis, and varying degrees of hypercalciuria. BS4A is associated with sensorineural deafness.
Protein type: Transporter; Membrane protein, integral; Membrane protein, multi-pass; Transporter, ion channel
Chromosomal Location of Human Ortholog: 1p32.1
Cellular Component: basolateral plasma membrane; integral to plasma membrane; plasma membrane; protein complex
Molecular Function: chloride channel activity; voltage-gated chloride channel activity
Disease: Bartter Syndrome, Type 4a
Research Articles on BSND
1. results demonstrate that the carboxyl terminus of hClC-Kb is not part of the for barttin, but functionally modifies the interplay with barttin.
Precautions
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Disclaimer
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