Full Product Name
Phospho-Alk (Tyr 1586)
Product Synonym Names
Anaplastic lymphoma kinase; CD246
Product Gene Name
anti-ALK antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9UM73
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Immunogen affinity purified
Storage Buffer
1*TBS (pH7.4), 1% BSA, 40% Glycerol.
Preservative
0.05% Sodium Azide.
Preparation and Storage
Aliquot and store at-20 degree C. Avoid repeated freeze/thaw cycles.
Other Notes
Small volumes of anti-ALK antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-ALK antibody
Western Blot (WB), Immunofluorescence (IF)
NCBI/Uniprot data below describe general gene information for ALK. It may not necessarily be applicable to this product.
NCBI Accession #
NP_004295.2
[Other Products]
NCBI GenBank Nucleotide #
NM_004304.4
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UniProt Primary Accession #
Q9UM73
[Other Products]
UniProt Secondary Accession #
Q4ZFX9; Q53QQ6; Q53RZ4; Q59FI3; Q9Y4K6[Other Products]
UniProt Related Accession #
Q9UM73[Other Products]
Molecular Weight
176,442 Da
NCBI Official Full Name
ALK tyrosine kinase receptor isoform 1
NCBI Official Synonym Full Names
ALK receptor tyrosine kinase
NCBI Official Symbol
ALK??[Similar Products]
NCBI Official Synonym Symbols
CD246; NBLST3
??[Similar Products]
NCBI Protein Information
ALK tyrosine kinase receptor
UniProt Protein Name
ALK tyrosine kinase receptor
UniProt Synonym Protein Names
Anaplastic lymphoma kinase; CD_antigen: CD246
Protein Family
Alkylsulfatase
UniProt Gene Name
ALK??[Similar Products]
NCBI Summary for ALK
This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).[provided by RefSeq, Jan 2011]
UniProt Comments for ALK
Neuronal receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system. Transduces signals from ligands at the cell surface, through specific activation of the mitogen-activated protein kinase (MAPK) pathway. Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif. Following activation by ligand, ALK induces tyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1, as well as of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Acts as a receptor for ligands pleiotrophin (PTN), a secreted growth factor, and midkine (MDK), a PTN-related factor, thus participating in PTN and MDK signal transduction. PTN-binding induces MAPK pathway activation, which is important for the anti-apoptotic signaling of PTN and regulation of cell proliferation. MDK-binding induces phosphorylation of the ALK target insulin receptor substrate (IRS1), activates mitogen-activated protein kinases (MAPKs) and PI3-kinase, resulting also in cell proliferation induction. Drives NF-kappa-B activation, probably through IRS1 and the activation of the AKT serine/threonine kinase. Recruitment of IRS1 to activated ALK and the activation of NF-kappa-B are essential for the autocrine growth and survival signaling of MDK.
Research Articles on ALK
1. point out the importance of taking into account both histopathologic and ALK immunohistochemical features to interpret ALK fluorescence in situ hybridization analyses in inflammatory and necrotic tumors
Precautions
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Disclaimer
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