Product Name
CEP152, Polyclonal Antibody
Full Product Name
CEP152 Antibody
Product Synonym Names
CE152; centrosomal protein 152 kDa; centrosomal protein 152kDa; centrosomal protein of 152 kDa
Product Gene Name
anti-CEP152 antibody
[Similar Products]
Product Synonym Gene Name
CE152[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for O94986
Species Reactivity
Human, Mouse
Specificity
CEP152 Antibody detects endogenous levels of total CEP152 protein.
Purity/Purification
Purified from rabbit antiserum by affinity-chromatography using immunogen.
Form/Format
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1 mg/ml (lot specific)
Target Modification
Unmodified/Total
Immunogen
The antiserum was produced against synthesized peptide derived from human CEP152.
Preparation and Storage
Stable at -20 degree C for at least 1 year.
Other Notes
Small volumes of anti-CEP152 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-CEP152 antibody
Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-CEP152 antibody
IHC: 1:50~1:100
ELISA: 1:40000
Immunohistochemistry (IHC) of anti-CEP152 antibody
Immunohistochemistry analysis of paraffin-embedded human lymph node tissue, using CEP152 Antibody. The picture on the right is blocked with the synthesized peptide.
NCBI/Uniprot data below describe general gene information for CEP152. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001181927.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001194998.1
[Other Products]
UniProt Primary Accession #
O94986
[Other Products]
UniProt Secondary Accession #
Q17RV1; Q6NTA0; E7ER66[Other Products]
UniProt Related Accession #
O94986[Other Products]
NCBI Official Full Name
centrosomal protein of 152 kDa isoform 1
NCBI Official Synonym Full Names
centrosomal protein 152
NCBI Official Symbol
CEP152??[Similar Products]
NCBI Official Synonym Symbols
MCPH4; MCPH9; SCKL5
??[Similar Products]
NCBI Protein Information
centrosomal protein of 152 kDa
UniProt Protein Name
Centrosomal protein of 152 kDa
Protein Family
Centrosomal protein
UniProt Gene Name
CEP152??[Similar Products]
UniProt Synonym Gene Names
KIAA0912; Cep152??[Similar Products]
NCBI Summary for CEP152
This gene encodes a protein that is thought to be involved with centrosome function. Mutations in this gene have been associated with primary microcephaly (MCPH4). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2010]
UniProt Comments for CEP152
Necessary for centrosome duplication; the function seems also to involve CEP63, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806). Acts as a molecular scaffold facilitating the interaction of PLK4 and CENPJ, 2 molecules involved in centriole formation (PubMed:21059844, PubMed:20852615). Proposed to snatch PLK4 away from PLK4:CEP92 complexes in early G1 daughter centriole and to reposition PLK4 at the outer boundary of a newly forming CEP152 ring structure (PubMed:24997597). Also plays a key role in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles (). Overexpression of CEP152 can drive amplification of centrioles (PubMed:20852615).
Research Articles on CEP152
1. Plk4 is intricately regulated in time and space through ordered interactions with two distinct scaffolds, Cep192 and Cep152, and a failure in this process may lead to human cancer.
Precautions
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Disclaimer
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