For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 3; NC_000003.11 (165490692..165555260, complement). Location: 3q26.1-q26.2

Highly Purified
95%, as determined by SDS-PAGE under reducing conditions and visualized by silver stain.

Supplied as a lyophilized powder in 0.2um sterile-filtered solution of 25mM tris, 0.15 M NaCl, pH 7.5.

12 months from date of receipt, 20 to 70 degree C as supplied.
1 month, 2 to 8 degree C under sterile conditions after reconstitution.
3 months, 20 to 70 degree C under sterile conditions after reconstitution.
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

Small volumes of BCHE recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Molecular Biology; MB-Enzymes

The purified, secreted rmBCHE has a N-terminal sequence, H28TEEDFIITT. The 582 amino acid residue rmBCHE predicts a molecular mass of 66kD. By SDS-PAGE under reducing conditions,
the protein migrates with a molecular mass of approximately 86kD. [the+protein+migrates+with+a+molecular+mass+of+approximately+86kD.+" title="Find similar products with The purified, secreted rmBCHE has a N-terminal sequence, H28TEEDFIITT. The 582 amino acid residue rmBCHE predicts a molecular mass of 66kD. By SDS-PAGE under reducing conditions,
the protein migrates with a molecular mass of approximately 86kD. ">Similar Products]

butyrylcholinesterase

cholinesterase; cholinesterase 1; choline esterase II; pseudocholinesterase; butyrylcholine esterase; cholinesterase (serum) 2; acylcholine acylhydrolase

Cholinesterase

CHE1??[Similar Products]

CHLE_HUMAN

Mutant alleles at the BCHE locus are responsible for suxamethonium sensitivity. Homozygous persons sustain prolonged apnea after administration of the muscle relaxant suxamethonium in connection with surgical anesthesia. The activity of pseudocholinesterase in the serum is low and its substrate behavior is atypical. In the absence of the relaxant, the homozygote is at no known disadvantage. [provided by RefSeq, Jul 2008]

BCHE: Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters. Defects in BCHE are the cause of butyrylcholinesterase deficiency (BChE deficiency). BChE deficiency is a metabolic disorder characterized by prolonged apnoea after the use of certain anesthetic drugs, including the muscle relaxants succinylcholine or mivacurium and other ester local anesthetics. The duration of the prolonged apnoea varies significantly depending on the extent of the enzyme deficiency. BChE deficiency is a multifactorial disorder. The hereditary condition is transmitted as an autosomal recessive trait. Belongs to the type-B carboxylesterase/lipase family.

Protein type: EC 3.1.1.8; Secreted; Hydrolase; Nuclear envelope; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 3q26.1-q26.2

Cellular Component: membrane; nuclear envelope lumen; endoplasmic reticulum lumen; extracellular region

Molecular Function: identical protein binding; choline binding; enzyme binding; cholinesterase activity; beta-amyloid binding; acetylcholinesterase activity; catalytic activity

Biological Process: response to alkaloid; response to drug; negative regulation of cell proliferation; cellular protein metabolic process; choline metabolic process; cocaine metabolic process; response to folic acid; response to glucocorticoid stimulus; neuroblast differentiation; learning; negative regulation of synaptic transmission

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