Product Name
4-1BBL, Polyclonal Antibody
Full Product Name
Rabbit Anti-Human 4-1BBL
Product Synonym Names
Antigen-Affinity Purified Polyclonal Antibodies Anti-human 4-1BBL
Product Gene Name
anti-4-1BBL antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 19; NC_000019.10 (6528562..6535928). Location: 19p13.3
3D Structure
ModBase 3D Structure for P41273
Purity/Purification
Antigen-Affinity chromatography
Antibody Generation
Produced from sera of rabbits pre-immunized with highly pure (>98%) recombinant h4-1BBL (human 4-1BBLigand). Anti-Human 4-1BBL specific antibody was purified by affinity chromatography employing immobilized h4-1BBL matrix.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-4-1BBL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-4-1BBL antibody
4-1BBL, a member of the TNF superfamily, is expressed in B cells, dendritic cells, activated T cells and macrophages. 4-1BBL binds to its receptor 4-1BB, and provides a co-stimulatory signal for T cell activation and expansion. The human 4-1BBL gene codes for a 254 amino acid type II transmembrane containing a 28 amino acid cytoplasmic domain, a 21 amino acid transmembrane domain, and a 205 amino acid extracellular domain. The soluble form of 4-1BBL contains the TNF-like portion of the extracellular domain of 4-1BBL. Recombinant human 4-1BBL is a soluble 19.5 kDa protein consisting of 185 amino acid residues.
Applications Tested/Suitable for anti-4-1BBL antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-4-1BBL antibody
Western Blot: To detect h4-1BBL by Western Blot analysis this antibody can be used at a concentration of 0.1 - 0.2 ug/ml. Used in conjunction with compatible secondary reagents the detection limit for recombinant h4-1BBL is 1.5 - 3.0 ng/lane, under either reducing or non-reducing conditions.
NCBI/Uniprot data below describe general gene information for 4-1BBL. It may not necessarily be applicable to this product.
NCBI Accession #
NP_003802.1
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NCBI GenBank Nucleotide #
NM_003811.3
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UniProt Primary Accession #
P41273
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UniProt Secondary Accession #
Q2M3S2[Other Products]
UniProt Related Accession #
P41273[Other Products]
Molecular Weight
26,625 Da
NCBI Official Full Name
tumor necrosis factor ligand superfamily member 9
NCBI Official Synonym Full Names
tumor necrosis factor (ligand) superfamily, member 9
NCBI Official Symbol
TNFSF9??[Similar Products]
NCBI Official Synonym Symbols
CD137L; 4-1BB-L
??[Similar Products]
NCBI Protein Information
tumor necrosis factor ligand superfamily member 9; 4-1BBL; 4-1BB ligand; receptor 4-1BB ligand; homolog of mouse 4-1BB-L
UniProt Protein Name
Tumor necrosis factor ligand superfamily member 9
UniProt Synonym Protein Names
4-1BB ligand
UniProt Gene Name
TNFSF9??[Similar Products]
UniProt Synonym Gene Names
4-1BBL??[Similar Products]
UniProt Entry Name
TNFL9_HUMAN
NCBI Summary for 4-1BBL
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.[provided by RefSeq, Oct 2008]
UniProt Comments for 4-1BBL
Function: Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages. Ref.3
Subunit structure: Homotrimer. Ref.3
Subcellular location: Membrane; Single-pass type II membrane protein.
Tissue specificity: Expressed in brain, placenta, lung, skeletal muscle and kidney.
Sequence similarities: Belongs to the tumor necrosis factor family.
Research Articles on 4-1BBL
1. this is the first study to indicate that this member of the TNF superfamily, CD137, is modulated by SAHA treatment in breast
Precautions
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Disclaimer
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