Product Name
4-hydroxyphenylpyruvate dioxygenase (HPD), Polyclonal Antibody
Full Product Name
Rabbit anti-human 4-hydroxyphenylpyruvate dioxygenase polyclonal Antibody
Product Synonym Names
4-hydroxyphenylpyruvate dioxygenase; HPD; 4-HPPD; 4HPPD; GLOD3; PPD
Product Gene Name
anti-HPD antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse
Purity/Purification
Antigen Affinity Purified
Storage Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-69282 / sc-69284 / sc-98596
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-HPD antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-HPD antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
NCBI/Uniprot data below describe general gene information for HPD. It may not necessarily be applicable to this product.
NCBI Accession #
AAC73008.1
[Other Products]
UniProt Secondary Accession #
Q13234; A8K461; B3KQ63[Other Products]
UniProt Related Accession #
P32754[Other Products]
Molecular Weight
40,497 Da[Similar Products]
NCBI Official Full Name
4-hydroxyphenylpyruvate-dioxygenase
NCBI Official Synonym Full Names
4-hydroxyphenylpyruvate dioxygenase
NCBI Official Symbol
HPD??[Similar Products]
NCBI Official Synonym Symbols
PPD; 4HPPD; GLOD3; 4-HPPD; HPPDASE
??[Similar Products]
NCBI Protein Information
4-hydroxyphenylpyruvate dioxygenase; glyoxalase domain containing 3; 4-hydroxyphenylpyruvic acid oxidase
UniProt Protein Name
4-hydroxyphenylpyruvate dioxygenase
UniProt Synonym Protein Names
4-hydroxyphenylpyruvic acid oxidase; 4HPPD; HPD; HPPDase
Protein Family
4-hydroxyphenylpyruvate dioxygenase
UniProt Gene Name
HPD??[Similar Products]
UniProt Synonym Gene Names
PPD; 4HPPD; HPD; HPPDase??[Similar Products]
UniProt Entry Name
HPPD_HUMAN
NCBI Summary for HPD
The protein encoded by this gene is an enzyme in the catabolic pathway of tyrosine. The encoded protein catalyzes the conversion of 4-hydroxyphenylpyruvate to homogentisate. Defects in this gene are a cause of tyrosinemia type 3 (TYRO3) and hawkinsinuria (HAWK). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]
UniProt Comments for HPD
HPD: Key enzyme in the degradation of tyrosine. Defects in HPD are the cause of tyrosinemia type 3 (TYRO3). TYRO3 is an inborn error of metabolism characterized by elevations of tyrosine in the blood and urine, seizures and mild mental retardation. Defects in HPD are a cause of hawkinsinuria (HAWK). HAWK is an inborn error of tyrosine metabolism characterized by failure to thrive, persistent metabolic acidosis, fine and sparse hair, and excretion of the unusual cyclic amino acid metabolite, hawkinsin, in the urine. Belongs to the 4HPPD family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 1.13.11.27; Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - tyrosine; Oxidoreductase; Cofactor and Vitamin Metabolism - ubiquinone and other terpenoid-quinone biosynthesis
Chromosomal Location of Human Ortholog: 12q24.31
Cellular Component: cytosol
Molecular Function: 4-hydroxyphenylpyruvate dioxygenase activity; metal ion binding
Biological Process: L-phenylalanine catabolic process; tyrosine catabolic process
Disease: Hawkinsinuria; Tyrosinemia, Type Iii
Research Articles on HPD
1. Glutamine375 has a critical role for 4-HPPD in orientating the tail and ensuring the conformation of the terminal alpha-helix of the enzyme to maintain the integrity of the active site for biocatalysis.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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