4-hydroxyphenylpyruvic acid oxidase

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

The antibody detects endogenous level of total 4-hydroxyphenylpyruvate dioxygenase polyclonal antibody.

Caprylic Acid Ammonium Sulfate Precipitation purified

Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

1.0 mg/ml (lot specific)

Store at -20 degree C

Small volumes of anti-HPD antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Key enzyme in the degradation of tyrosine.

Total protein Ab

Immunohistochemistry (IHC)

Immunohistochemistry: 1:20 - 1:200

Immunohistochemical analysis of paraffin-embedded human colon cancer using at dilution of 1:20.

40,497 Da[Similar Products]

4-hydroxyphenylpyruvate dioxygenase

4-hydroxyphenylpyruvate dioxygenase

4-hydroxyphenylpyruvate dioxygenase

PPD; 4HPPD; HPD; HPPDase??[Similar Products]

HPPD_HUMAN

HPD: Key enzyme in the degradation of tyrosine. Defects in HPD are the cause of tyrosinemia type 3 (TYRO3). TYRO3 is an inborn error of metabolism characterized by elevations of tyrosine in the blood and urine, seizures and mild mental retardation. Defects in HPD are a cause of hawkinsinuria (HAWK). HAWK is an inborn error of tyrosine metabolism characterized by failure to thrive, persistent metabolic acidosis, fine and sparse hair, and excretion of the unusual cyclic amino acid metabolite, hawkinsin, in the urine. Belongs to the 4HPPD family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - tyrosine; Cofactor and Vitamin Metabolism - ubiquinone and other terpenoid-quinone biosynthesis; EC 1.13.11.27; Oxidoreductase

Chromosomal Location of Human Ortholog: 12q24.31

Cellular Component: cytosol; endoplasmic reticulum membrane; Golgi membrane

Molecular Function: 4-hydroxyphenylpyruvate dioxygenase activity

Biological Process: L-phenylalanine catabolic process; tyrosine catabolic process

Disease: Hawkinsinuria; Tyrosinemia, Type Iii

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