Full Product Name
AID Polyclonal Antibody
Product Synonym Names
AICDA; AID; Activation-induced cytidine deaminase; Cytidine aminohydrolase
Product Gene Name
anti-AID antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9GZX7
Species Reactivity
Human, Mouse, Rat
Specificity
AID Polyclonal Antibody detects endogenous levels of AID protein.
Purity/Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration
1 mg/ml (lot specific)
Immunogen Description
Synthesized peptide derived from the Internal region of human AID.
Preparation and Storage
Store at -20 degree C/1 year
Other Notes
Small volumes of anti-AID antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-AID antibody
Total protein Ab
Applications Tested/Suitable for anti-AID antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-AID antibody
Western Blot: 1:500 - 1:2000
ELISA: 1:10000
Not yet tested in other applications.
Western Blot (WB) of anti-AID antibody
Western Blot analysis of Hela HepG2 cells using AID Polyclonal Antibody
NCBI/Uniprot data below describe general gene information for AID. It may not necessarily be applicable to this product.
NCBI Accession #
NP_065712.1
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NCBI GenBank Nucleotide #
NM_020661.2
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UniProt Primary Accession #
Q9GZX7
[Other Products]
UniProt Secondary Accession #
Q6QJ81; Q8NFC1[Other Products]
UniProt Related Accession #
Q9GZX7[Other Products]
Molecular Weight
22,614 Da
NCBI Official Full Name
single-stranded DNA cytosine deaminase
NCBI Official Synonym Full Names
activation-induced cytidine deaminase
NCBI Official Symbol
AICDA??[Similar Products]
NCBI Official Synonym Symbols
AID; ARP2; CDA2; HIGM2; HEL-S-284
??[Similar Products]
NCBI Protein Information
single-stranded DNA cytosine deaminase
UniProt Protein Name
Single-stranded DNA cytosine deaminase
UniProt Synonym Protein Names
Activation-induced cytidine deaminase; Cytidine aminohydrolase
Protein Family
AIDA-I autotransporter
UniProt Gene Name
AICDA??[Similar Products]
UniProt Synonym Gene Names
AID??[Similar Products]
UniProt Entry Name
AICDA_HUMAN
NCBI Summary for AID
This gene encodes a RNA-editing deaminase that is a member of the cytidine deaminase family. The protein is involved in somatic hypermutation, gene conversion, and class-switch recombination of immunoglobulin genes. Defects in this gene are the cause of autosomal recessive hyper-IgM immunodeficiency syndrome type 2 (HIGM2). [provided by RefSeq, Feb 2009]
UniProt Comments for AID
AID: Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation, gene conversion, and class- switch recombination in B-lymphocytes. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. Strongly expressed in lymph nodes and tonsils. Belongs to the cytidine and deoxycytidylate deaminase family.
Protein type: EC 3.5.4.38; Hydrolase
Chromosomal Location of Human Ortholog: 12p13
Cellular Component: cytoplasm; exosome (RNase complex); nucleus
Molecular Function: protein binding; zinc ion binding; ubiquitin protein ligase binding; cytidine deaminase activity
Biological Process: somatic diversification of immunoglobulins; B cell differentiation; somatic hypermutation of immunoglobulin genes; isotype switching; cytidine deamination; mRNA processing
Disease: Immunodeficiency With Hyper-igm, Type 2
Research Articles on AID
1. hnRNP K and hnRNP L may serve as A1CF-like cofactors in AID-mediated class switch recombination and somatic hypermutation
Precautions
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Disclaimer
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