Product Name
Adrenergic Receptor alpha-2C (ADRA2C), Antibody
Full Product Name
Adrenergic Receptor alpha-2C Antibody
Product Synonym Names
Alpha-2C adrenergic receptor; Alpha-2C adrenoceptor; Alpha-2C adrenoreceptor; Alpha-2 adrenergic receptor subtype C4; ADRA2L2; ADRA2RL2
Product Gene Name
anti-ADRA2C antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P18825
Species Reactivity
Human, Mouse, Rat
Specificity
Adrenergic Receptor alpha-2C antibody detects endogenous levels of total Adrenergic Receptor alpha-2C protein.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen
The antiserum was produced against synthesized peptide derived from internal of human Adrenergic Receptor alpha-2C.
Preparation and Storage
Store at-20 degree C for 1 year.
Other Notes
Small volumes of anti-ADRA2C antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-ADRA2C antibody
Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
Applications Tested/Suitable for anti-ADRA2C antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-ADRA2C antibody
WB: 1:500-1:1000
ELISA: 1:10000
Western Blot (WB) of anti-ADRA2C antibody
Western blot analysis of extracts from HepG2 cells, using Adrenergic Receptor alpha-2C antibody.
NCBI/Uniprot data below describe general gene information for ADRA2C. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000674.2
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NCBI GenBank Nucleotide #
NM_000683.3
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UniProt Primary Accession #
P18825
[Other Products]
UniProt Secondary Accession #
P35369; Q9HB49[Other Products]
UniProt Related Accession #
P18825[Other Products]
Molecular Weight
49,522 Da
NCBI Official Full Name
alpha-2C adrenergic receptor
NCBI Official Synonym Full Names
adrenoceptor alpha 2C
NCBI Official Symbol
ADRA2C??[Similar Products]
NCBI Official Synonym Symbols
ADRA2L2; ADRARL2; ADRA2RL2; ALPHA2CAR
??[Similar Products]
NCBI Protein Information
alpha-2C adrenergic receptor
UniProt Protein Name
Alpha-2C adrenergic receptor
UniProt Synonym Protein Names
Alpha-2 adrenergic receptor subtype C4; Alpha-2C adrenoreceptor; Alpha-2C adrenoceptor; Alpha-2CAR
Protein Family
Alpha-2C adrenergic receptor
UniProt Gene Name
ADRA2C??[Similar Products]
UniProt Synonym Gene Names
ADRA2L2; ADRA2RL2; Alpha-2C adrenoceptor; Alpha-2CAR??[Similar Products]
NCBI Summary for ADRA2C
Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The mouse studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences. [provided by RefSeq, Jul 2008]
UniProt Comments for ADRA2C
Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.
Product References and Citations for anti-ADRA2C antibody
Regan J.W., Proc. Natl. Acad. Sci. U.S.A. 85:6301-6305(1988). Schaak S., Biochem. J. 328:431-438(1997). Small K.M., J. Biol. Chem. 275:23059-23064(2000).
Research Articles on ADRA2C
1. The frequency of alpha2CDel322-325-AR in suicide and non-suicide victims was similar. Genotype frequencies for the alpha2CDel322-325-AR polymorphism in depressed and schizophrenic subjects were higher than in controls, but these differences did not reach statistical significance. The results indicate that alpha2CDel322-325-AR may play a role in the pathophysiology of opiate abuse and dependence.
Precautions
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Disclaimer
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